Topographic Distribution of Catecholaminergic Neurons in the Rat Medulla Oblongata Using Quantitative Three-Dimensional Reconstruction

  • M. Kalia
  • D. J. Woodward
  • W. K. Smith
  • K. Fuxe
  • T. Hökfelt
  • M. Goldstein
Part of the Wenner-Gren Center International Symposium Series book series (WGCISS, volume 42)


In 1964 Dahlstrom and Fuxe (3), using the formaldehyde histofluorescence technique, first described a variety of monoamine containing neurons in the brain. A number of studies on the catecholamine (CA) neurons followed, (2,4–8,12–19,,24,) resulting in the demonstration of the existence of the following populations of CA neurons: adrenaline containing neurons — C cell groups (Hokfelt, Fuxe et al, 1974), noradrenaline containing neurons — A cell groups (Dahlstrom and Fuxe, 1964) and dopamine containing neurons. Historically, the question of monoaminergic neurons located in the brain stem has been addressed using fluorescence histochemistry and immunofluorescence techniques (1,2,3,18,19,30).


Cell Group Area Postrema Dorsal Motor Nucleus Acta Physiol Computer Reconstruction 
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Copyright information

© The Wenner-Gren Centre 1985

Authors and Affiliations

  • M. Kalia
    • 1
  • D. J. Woodward
    • 2
  • W. K. Smith
    • 2
  • K. Fuxe
    • 3
  • T. Hökfelt
    • 3
  • M. Goldstein
    • 4
  1. 1.Department of PharmacologyThomas Jefferson UniversityPhiladelphiaUSA
  2. 2.Department of Cell BiologyUniversity of Texas Health Science Center at DallasDallasUSA
  3. 3.Department of HistologyKarolinska InstitutetStockholmSweden
  4. 4.Department of PsychiatryNew York University Medical CenterNew YorkUSA

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