Abstract
The objectives of our cytochemical investigations of neurotransmitter systems have been to use cellular circuitry in the mammalian brain as a basis for functional insight. It has been our view that the most meaningful analysis of transmitter actions at the cellular level rely on an accurate determination as to the origin and targets of a specific transmitter containing system (Bloom, 1975). As a result, we have frequently resorted to detailed manual quantitative analysis of cytochemical features as possible indices to the identification of GABA (Iversen and Bloom, 1972) or noradrenergic terminals (Bloom and Aghajanian, 1968a; Koda and Bloom, 1977), or for the temporal development of synaptic systems (Aghajanian and Bloom, 1967; Bloom and Aghajanian, 1968b; Woodward et al, 1971). The utility of such enterprises, suggests that there is a highly useful purpose to be served by quantitative studies of neurotransmitter distribution and synaptic density. Acquiring similar data sets is time-consuming, labor intensive, and open to the problems of human error, thus limiting the application of such methods. A solution to this quandry can only be accomplished by computers.
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© 1985 The Wenner-Gren Centre
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Morrison, J.H., Bloom, F.E. (1985). Quantitative Studies of Rodent and Primate Neocortex: Central Monoamine and Peptide Neurons. In: Agnati, L.F., Fuxe, K. (eds) Quantitative Neuroanatomy in Transmitter Research. Wenner-Gren Center International Symposium Series, vol 42. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2139-2_14
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DOI: https://doi.org/10.1007/978-1-4613-2139-2_14
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