Aneuploidy pp 133-148 | Cite as

Genetic Factors Influencing Aneuploidy Frequency

  • Dorothy Warburton
Part of the Basic Life Sciences book series (BLSC, volume 36)

Abstract

The presence of significant genetic or environmental risk factors for aneuploidy in the human population will almost certainly lead to heterogeneity of risk for aneuploidy among couples at risk. Such heterogeneity may be observed as a higher risk of aneuploidy among couples who have already had one aneuploid pregnancy than among those who have not. In the first section of this chapter I will discuss the existing data concerning the existence of “aneuploidy-prone” individuals or couples. I will then review a number of genetic factors which have been suggested to lead to an increased risk for human aneuploidy, examining the often conflicting evidence for such an association and possible mechanisms of action.

Keywords

Stein Infertility Kuwait Pregnan Etiol 

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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Dorothy Warburton
    • 1
  1. 1.Department of Pediatrics and Human Genetics and DevelopmentColumbia UniversityNew YorkUSA

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