Aneuploidy pp 149-164 | Cite as

Environmental Causes of Aneuploidy: Why So Elusive?

  • Jennie Kline
  • Zena Stein
Part of the Basic Life Sciences book series (BLSC, volume 36)


Before the development of techniques to karyotype the spontaneously aborted conceptus, studies of human aneuploidy were based on livebirths and focused almost entirely on the most common anomalies among births: abnormalities of the sex chromosomes and trisomy 21. Various studies repeatedly showed an increase in the prevalence of trisomy 21 births with maternal age, the rapid increase beginning in the mid-30s. Trisomy 13 and 18 births showed similar associations with maternal age (see Ref. 21). No other parental characteristic, including paternal age, and no environmental exposure has shown a consistent association with trisomy 21 among births.


Down Syndrome Spontaneous Abortion Maternal Smoking Coffee Consumption Collaborative Perinatal Project 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Jennie Kline
    • 1
    • 2
  • Zena Stein
    • 1
    • 2
  1. 1.New York State Psychiatric InstituteNew YorkUSA
  2. 2.Sergievsky Center and School of Public HealthColumbia UniversityUSA

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