Hippocampal Pyramidal Cells: Ionic Conductance and Synaptic Interactions
The burst firing pattern of the hippocampal pyramidal cells was first described by Kandel and Spencer in their intracellular studies using the in vivo cat preparation (Kandel and Spencer, 1961). Subsequently, the ionic basis for action potential generation in the hippocampal pyramidal cells has been extensively studied in the hippocampal slice. Data derived from the in vitro preparation also demonstrated that the bursting pattern provided a basis for the generation of synchronized population oscillation in the hippocampus. In this chapter we describe the membrane conductance system of the pyramidal cells that allows burst generation. In addition, we summarize the way synaptic interaction can occur between these bursting cells to bring about population synchrony.
KeywordsHippocampal Neuron Pyramidal Cell Outward Current Synchronization Process Burst Firing
Unable to display preview. Download preview PDF.
- Alger, B. E. and Nicoll, R. A., 1982, Feed-forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro, J. Physiol. (London) 328: 105–123.Google Scholar
- Brown, D. A. and Griffith, W. H., 1983a, Calcium activated outward current in voltage-clamped hippocampal neurones of the guinea-pig, J. Physiol. (London) 337: 287–301.Google Scholar
- Brown, D. A. and Griffith, W. H., 1983b, Persistent slow inward calcium current in voltage-clamped hippocampal neurones of the guinea-pig, J. Physiol. (London) 337: 303–320.Google Scholar
- Miles, R. and Wong, R. K. S., 1984, Unitary inhibitory synaptic potentials in the guinea pig hippocampus in vitro, J. Physiol. (London) 356: 97–113.Google Scholar
- Wong, R. K. S. and Traub, R. D., 1983, Synchronized burst discharge in the disinhibited hippocampal slice. I. Initiation in the CA2-CA3 region, J. Neurophysiol. 48: 938–951.Google Scholar