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Electrochemistry of Drug Interactions and Incompatibilities

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Modern Bioelectrochemistry

Abstract

Molecular associations involving drugs are of considerable pharmacological importance. Incompatibilities and the binding of “active” drugs to “inert” formulation components are characterized by such associations and may result in rendering otherwise carefully planned therapeutic regimens ineffective. The “large cation—large anion” incompatibility is considered. Association between two drugs or a drug and tissue component in vivo may greatly modify the distribution and therefore the therapeutic effect of the drug. In spite of complications caused by tissue binding and metabolic modification the therapeutic interaction between some pairs of drugs is suitable for study by physicochemical in vitro techniques. Further details with respect to the interactions of the anticoagulant heparin are given. The study of the mechanism of drug action is greatly assisted by the in vitro study of simplified model systems. The chlorpromazine/iodine system is discussed. Electrochemical techniques, such as conductimetric titration, voltammetry, and potentiometry, are indicated when there is a decrease (as in cation—anion association) or increase (as in the dissociation of a charge transfer complex) in the concentration of charge carriers. Other physicochemical techniques are complementary with these electrochemical techniques. Biological and clinical studies are essential before deciding the practical therapeutic significance of an interaction demonstrated by physicochemical means.

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Authors and Affiliations

  1. Clinical Pharmacologist, The St. George Hospital, Kogarah, N.S.W., 2217, Australia

    G. M. Eckert

  2. School of Chemistry, Macquarie University, North Ryde, N.S.W., 2113, Australia

    F. Gutmann

  3. Department of Chemistry and Biochemistry, California State University, 5151 State University Drive, Los Angeles, California, 90032, USA

    H. Keyzer

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  1. G. M. Eckert
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  2. F. Gutmann
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  3. H. Keyzer
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Editors and Affiliations

  1. School of Chemistry, Macquarie University, North Ryde, New South Wales, 2113, Australia

    Felix Gutmann

  2. Department of Chemistry and Biochemistry, California State University, 5151 State University Drive, Los Angeles, California, 90032, USA

    Hendrik Keyzer

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© 1986 Plenum Press, New York

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Eckert, G.M., Gutmann, F., Keyzer, H. (1986). Electrochemistry of Drug Interactions and Incompatibilities. In: Gutmann, F., Keyzer, H. (eds) Modern Bioelectrochemistry. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2105-7_19

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  • DOI: https://doi.org/10.1007/978-1-4613-2105-7_19

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