A Qualitative, Molecular Model of the Nerve Impulse

Conductive Properties of Unsaturated Lyotropic Liquid Crystals
  • Paavo K. J. Kinnunen
  • Jorma A. Virtanen

Abstract

An approach to the molecular mechanism of nerve impulse is described. Basically, we propose an electronic conduction band to exist in properly arranged ethylenic double bonds of unsaturated nerve membrane lipids. Electron-electron interaction in the conduction band is brought about by a pair of holes residing on a charge-transfer band of cholesterol and phospholipid carbonyls. Rectification of signal and driving force for propagation is provided by transmembrane ion fluxes which generate a lateral field along the axis of the nerve fiber. Transmembrane ion currents are controlled by Na-channel proteins, which in turn are regulated by a transient phase transition in the membrane lipids. In the latter process a crucial role is played by phosphatidylserine. Under resting potential this lipid in the outer surface of the membrane is deprotonated and in the liquid crystalline state. Following a depolarizing pulse an electrostatically triggered phase transition takes place due to protonation of phosphatidylserine with subsequent phase separation of a crystalline membrane lipid domain and opening of Na channels

Keywords

Permeability Iodine Carbonyl Lidocaine Cyclohexane 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Paavo K. J. Kinnunen
    • 1
  • Jorma A. Virtanen
    • 1
  1. 1.Department of Medical Chemistry and Department of ChemistryUniversity of HelsinkiHelsinki 17Finland

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