Skip to main content

Abstract

The purpose of this paper is to review experimental evidence and to discuss physico-chemical interpretations concerning the interaction between cell surface receptors and ELF fields. The analysis will be limited to fields with an r. m. s. intensity not larger than 10 V/cm. Emphasis will be put on the electric component of the electromagnetic perturbation and those experimental approaches will be privileged which stress the measurements of electro-chemical properties of cell membrane receptors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S. J. Singer, G. Nicolson: “The fluid mosaic model of the structure of cell membranes” Science, 175: 720, (1972)

    Article  ADS  Google Scholar 

  2. S. Nir, M. Anderson: “Van der Waals interactions between cell surfaces” J. Membrane Biol., 31: 1, (1977)

    Article  Google Scholar 

  3. G. Nicolson: “Transmembrane control of the receptors on normal and tumor cells” Biochimica et Biophysica Acta, 457: 57, (1976)

    Google Scholar 

  4. R. C. Weisenberg: “Microtubule formation in vitro in solutions containing low calcium concentrations” Science, 177: 1104, (1972)

    Article  ADS  Google Scholar 

  5. A. Chiabrera, M. Grattarola, M. Parodi: “Modelling of electrochemical processes in biological media under electromagnetic exposure” In “Mathematical Modeling in Biology”, NATO-ASI Series, Plenum, In the press

    Google Scholar 

  6. A. Levi, Y. Shecheler, E. Neufeld, J. Schlessinger: “Mobility, clustering and transport of nerve growth factor in embryonal sensory cells and in a symphatetic neuronal cell line” Proc. Natl. Acad. Sci., USA, 77: 3469, (1980)

    Article  ADS  Google Scholar 

  7. G. Rein: “Electromagnetic induction of neurotrasmitter release from a neuronal cell line” Presented at “International Conference on nonlinear electrodynamic in Biological Systems” June 5–9 1983 (Loma Linda, USA) Plenum, In press.

    Google Scholar 

  8. K. Balakrishnan, f. Hsu, A. Cooper, H. McConnell: “Lipid hapten containing membrane targets can trigger specific immunoglobulin E-dependent degranulation of rat basophil leukemia cells” The Journal of Biological Chemistry, 257, 1981.

    Google Scholar 

  9. C. DeLisi: “The biophysics of ligand-receptor interactions” Quartery review Biophysics, 132: 202, (1980)

    Google Scholar 

  10. A. Chiabrera, M. Grattarola, R. Viviani, C. Braccini: “Modelling of the perturbation induced by low-energy electromagnetic fields on the membrane/receptors of stimulated human lymphocytes. II Influence of the fields on the mean lifetimes of the aggregation process” Studia Biophysica, 91: 125, (1982)

    Google Scholar 

  11. H. Lis, N. Sharon: In: The Biochemistry of plants “Vol.6, “Lectins in higher plants” ( Marcus ed. ), Academic Press, (1981).

    Google Scholar 

  12. Z. Darzynkiewicz, E. Balazs: “Effect of connective tissue intercellular matrix on l3nnphocytes stimulation” Experimental Cell Research, 66: 113 (1971)

    Article  Google Scholar 

  13. F. Beltrame, A. Chiabrera, M. Grattarola, P. Guerrini, G. C. Parodi, D. Ponta, G. Vernazza, R. Viviani: “Acta: Automated image anlysis system for absorption fluorescence and phase contrast studies of cell images” Proceedings 2nd Annual Conference of the Engineering in Medicine and Biology Society, 58 (1980)

    Google Scholar 

  14. R. Whitney, R. Sutherland: “Requirement for calcium ions in lymphocyte transformation stimulated by phytohemagglutinin” Cell Physiol. 80: 329, (1978)

    Article  Google Scholar 

  15. V. Maino, N. Green, M. Crumpton: “The role of calcium ions in initiating transformation of lymphocytes” Nature, 251: 324 (1978)

    Article  ADS  Google Scholar 

  16. R. Tsien, T. Pozzan, T. Rink: “T-cell mitogens cause early changes in cytoplasmatic free Ca-H- and membrane potential in lymphocytes” Nature, 295: 68, (1982)

    Article  ADS  Google Scholar 

  17. R. Y. Tsien, T. Pozzan, T. J. Rink: “Calcium homeostasis in intact l3rmphocytes: Cytoplasmic free calcium monitored with a new, intracellulary trapped fluorescent indicator” The Journal of Cell Biology, 94: 325, (1982).

    Article  Google Scholar 

  18. F. Beltrame, A. Chiabrera, A. Gliozzi, M. Grattarola, G. Parodi, D. Vecchio, D. Ponta, G. Vernazza, R. Viviani: “Electromagnetic control of cell reactivation” Proceedings Symposium URSI “Electromagnetic waves and biology” 33, (1980)

    Google Scholar 

  19. D. Lyle, P. Schechter, W. Ross Adey, R. Lundak: “Suppression of T-lymphocyte cytotoxicity following exposure to sinusoidally amplitude modulated fields” Bioelectromagnetics, 4: 281, (1983)

    Article  Google Scholar 

  20. R. Lüben, C. Cain, M. Chen, D. Rosen, W. Ross Adey: “Effects of electromagnetic stimuli on bone and bone cell “in vitro”: Inhibition of responses to parathyroid hormone by low-energy low-frequency fields” Proc. Natl. Acad. Sci, USA, 79: 4180, (1982)

    Article  ADS  Google Scholar 

  21. R. Dziak, P. Stern: “Calcium transport in isolated bone cells III. Effects of parathyroid hormone and cyclic 3‵, 5‵-AMP” Endocrinology, 97: 1281, (1975)

    Article  Google Scholar 

  22. M. M. Poo, J. Lam, N. Orida, A. Chao: “Electrophoresis and diffusion in the plane of the cell membrane” Biophysical journal, 26: 1, (1979)

    Article  ADS  Google Scholar 

  23. M. M. Poo, K. Robinson: “Electrophoresis of Concanavalin A receptors along embryonic muscle cell membrane” Nature, 265: 602, (1977)

    Article  ADS  Google Scholar 

  24. S. Lin-Liu, M. M. Poo, W. R. Adey: “Migration of cell surface Concanavalin A receptors in pulsed electric fields” Bioelectromagnetics, in press

    Google Scholar 

  25. S. Young, M. M. Poo: “Topographic rearrangement of Ach receptors alters channel kinetics” Nature, 304: 161, (1983)

    Article  ADS  Google Scholar 

  26. N. Patel, M. M. Poo: “Orientation of neurite growth by extracellular electric fields” The Journal of Neuroscience, 2: 483, (1982)

    Google Scholar 

  27. S. McLaughlin, M. M. Poo: “The role of electro-osmosis in the electric field-induced movement of charged macromolecules on the surface of cells” Biophysical Journal, 34: 85, (1981)

    Article  ADS  Google Scholar 

  28. K. Cole : “Membranes, ions and impulses” University of California Press ( Berkeley, California USA ), (1972)

    Google Scholar 

  29. C. Tanford: “Physical Chemistry of Macromolecules” Wiley ed. (1961)

    Google Scholar 

  30. J. Rabinowitz: “The effect of electric field induced perturbation of of the distribution of ions near the cell surface on migration of charged membrane components” Journal Theoretical Biology, 99: 377, (1982)

    Article  Google Scholar 

  31. A. Lawrence, W. Ross Adey: “Nonlinear wave mechanisms in interactions between excitable tissue and electromagnetic fields” Neurological Research, 4: 114, (1982)

    Google Scholar 

  32. G. Bell: “Models for the specific adhesion of cells” Science, 200: 618, (1978)

    Article  ADS  Google Scholar 

  33. M. Grattarola, R. Viviani, A. Chiabrera: “Modelling of the perturbation induced by low-frequency electromagnetic fields on the membrane receptors of stimulated human lymphocytes. I. Influence of the fields on the systèmes free energy” Studia Biophysica, 91: 117, (1982)

    Google Scholar 

  34. S. Chandrasekhar: “Stochastic problems in physics and astronomy” Reviews of Modern Physics, 15: 1, (1943)

    Article  MathSciNet  ADS  MATH  Google Scholar 

  35. A. Chiabrera, M. Grattarola, R. Viviani: “Interaction between electromagnetic fields and cells: Microelectrophoretic effect of ligands and surface receptors” Bioelectromagnetics, in press.

    Google Scholar 

  36. A. Chiabrera, M. Hinsenkamp, A. A. Pilla, J. Ryaby, D. Ponta, A. Belmont, F. Beltrame M. Grattarola, C. Nicolini: “Cytofluorimetry of electromagnetically controlled cell de-differentiation” The Journal of Histochemistry and Cytochemistry, 27: 375, (1979).

    Article  Google Scholar 

  37. A. A. Pilla: “Electrochemical information transfer at living cell membrane-s” Ann. NY Acad. Sci. 238: 149, (1974).

    Article  ADS  Google Scholar 

  38. SD. Smith, CL. Thomas, SF. Frash: “Lanthanum inhibition of electrically induced dedifferentiation in frog erythrocytes” Bioelectrochem. Bioenerg. 5: 177, (1978).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Plenum Press, New York

About this chapter

Cite this chapter

Grattarola, M., Caratozzolo, F., Chiabrera, A. (1985). Interaction of ELF Electromagnetic Fields with Cell Membrane Receptors. In: Grandolfo, M., Michaelson, S.M., Rindi, A. (eds) Biological Effects and Dosimetry of Static and ELF Electromagnetic Fields. Ettore Majorana International Science Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2099-9_16

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2099-9_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9243-2

  • Online ISBN: 978-1-4613-2099-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics