Herpesvirus Sylvilagus: Lymphoproliferative Agent of Cottontail Rabbits

  • Amy K. Patick
  • Harry C. Hinze
Part of the Developments in Veterinary Virology book series (DVVI, volume 6)

Abstract

Herpesvirus sylvilagus is an indigenous virus of cottontail rabbits. Infection of rabbits results in a lymphoproliferative disorder characterized by spleen and lymph node hyperplasia, the appearance of atypical lymphocytes in the peripheral blood, and an intense T-cell proliferation. In vivo, the virus is present latently in B and T lymphocytes in both a covalently closed circular form and a linear duplex form. In vitro, the virus is able to bind to lymphocytes but a productive infection is not detected. In productively infected cultured rabbit kidney cells, the virus induces the synthesis of at least 45 virus-induced polypeptides of which at least 14 are glycosylated.

Keywords

Migration Agar Lymphoma Attenuation Electrophoresis 

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References

  1. 1.
    Hinze, H.C. Infect. Immun. 3:350–354, 1971.PubMedGoogle Scholar
  2. 2.
    Hinze, H.C. Bacteriol. Proc, 147, 1968.Google Scholar
  3. 3.
    Heine, U. and Hinze, H.C. Cancer Res. 32:1340–1350, 1972.PubMedGoogle Scholar
  4. 4.
    Becker, P., Melnick, J.L. and Mayor, H.O. Exp. Mol. Pathol. 4:11–23, 1965.CrossRefGoogle Scholar
  5. 5.
    Nii, S., Morgan, C. and Rose, H.M. J. Virol. 2:517–536, 1968.PubMedGoogle Scholar
  6. 6.
    Ley, K.D. and Burger, D. Appl. Microbiol. 19:549, 1970.PubMedGoogle Scholar
  7. 7.
    Hinze, H.C. and Chipman, P.J. Fed. Proc. 31:1639–1642, 1972.PubMedGoogle Scholar
  8. 8.
    Hinze, H.C. Int. J. Cancer 8:514–522, 1971.PubMedGoogle Scholar
  9. 9.
    Kramp, W.J., Medveczky, P., Mulder, C, Hinze, H.C. and Sullivan, J.L. J. Virol. 56:60–65, 1985.PubMedGoogle Scholar
  10. 10.
    Wegner, D.L. and Hinze, H.C. Int. J. Cancer 14:567–575, 1974.PubMedCrossRefGoogle Scholar
  11. 11.
    Niederman, J.C., Miller, G., Pearson, H.A., Pagano, J.S. and Dowaliby, J.M. N. Eng. J. med. 294:1355–1359, 1976.CrossRefGoogle Scholar
  12. 12.
    Falk, L.A., Nigida, S., Deinhardt, F., Cooper, R.W. and Hernandez-Camacho, J.I. J. natl. Cancer Inst. 51:1987–1989, 1973.PubMedGoogle Scholar
  13. 13.
    Hinze, H.C. and Lee, K.W. In: Viruses in naturally occuring cancers. Cold Spring Harbor Conferences on Cell Proliferation, Vol. 7. pp 163–169, 1980.Google Scholar
  14. 14.
    Calneck, B.W., Adldinger, H.K. and Kahn, D.E. Avian Dis. 14:219–233, 1970.CrossRefGoogle Scholar
  15. 15.
    Sixbey, J.W., Nedrud, J.G., Raab-Traub, N., Hanes, R.A., and Pagano, J.S. New Eng. J. Med. 310:1225–1230, 1984.PubMedCrossRefGoogle Scholar
  16. 16.
    Medveczky, P., Kramp, W.J. and Sullivan, J.L. J. Virol. 52:711–714, 1984.PubMedGoogle Scholar
  17. 17.
    Sheldrick, P., and Berthelot, N. Cold Spring Harbor Symp. Quant. Biol. 39:667–678, 1975.PubMedGoogle Scholar
  18. 18.
    Medveczky, M., Hinze, H.C. and Medveczky, P. 1985. Abstracts of Tenth International Herpesvirus Workshop, pp. 218, 1985.Google Scholar
  19. 19.
    Cohrs, R. and Rouhandeh, H. J. Virol. 41:1063, 1982.PubMedGoogle Scholar
  20. 20.
    Rouhandeh, H. and Cohrs, R. J. Virol. 52:1005, 1984.PubMedGoogle Scholar
  21. 21.
    Patlck, A.K. and Hinze, H.C. J. Virol. 52:976–980, 1984.Google Scholar
  22. 22.
    Honess, R.W. and Roizman, B. J. Virol. 14:8–19, 1974.PubMedGoogle Scholar
  23. 23.
    Rea, J.T., Timmins, J.G., Long, G.W. and Post, L.E. J. Virol. 54:21–29, 1985.PubMedGoogle Scholar
  24. 24.
    Isfort, J.R., Stringer, R.A., Kung, H.J. and Velicer, L.F. J. Virol. 57:464–474, 1986.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishers, Boston 1988

Authors and Affiliations

  • Amy K. Patick
    • 1
  • Harry C. Hinze
    • 1
  1. 1.Department of Medical MicrobiologyUniversity of Wisconsin Medical SchoolMadisonUSA

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