Herpesvirus Sylvilagus: Lymphoproliferative Agent of Cottontail Rabbits
Herpesvirus sylvilagus is an indigenous virus of cottontail rabbits. Infection of rabbits results in a lymphoproliferative disorder characterized by spleen and lymph node hyperplasia, the appearance of atypical lymphocytes in the peripheral blood, and an intense T-cell proliferation. In vivo, the virus is present latently in B and T lymphocytes in both a covalently closed circular form and a linear duplex form. In vitro, the virus is able to bind to lymphocytes but a productive infection is not detected. In productively infected cultured rabbit kidney cells, the virus induces the synthesis of at least 45 virus-induced polypeptides of which at least 14 are glycosylated.
KeywordsMigration Agar Lymphoma Attenuation Electrophoresis
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