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Graft-Versus-Host Disease and the Role of Blood Product Irradiation

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White cells and platelets in blood transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 19))

Abstract

Antigenic differences between the donor and the recipient in a blood transfusion may lead to a variety of immunologic reactions following transfusion. Most frequently, this involves immunologic rejection of transfused red cells, white cells, or platelets. However, on rare occasions the reaction may occur in the opposite direction, and immunologically active lymphocytes in a transfused unit may generate a severe reaction against the recipient. This is known as a graft-versus-host (GvH) reaction. It has become clear that GvH reactions may occur whenever immunologically competent allogeneic lymphocytes are transfused into an immunocompromized host.

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Authors
  1. S. F. Leitman M.D.
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Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    Cees Th. Smit Sibinga MD, PhD  & Prakash C. Das MD, PhD, FRCPath  & 

  2. Central Laboratory of the Netherlands Red Cross, Amsterdam, The Netherlands

    C. Paul Engelfriet MD, PhD (Chairman) (Chairman)

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© 1987 Martinus Nijhoff Publishing, Boston

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Leitman, S.F. (1987). Graft-Versus-Host Disease and the Role of Blood Product Irradiation. In: Sibinga, C.T.S., Das, P.C., Engelfriet, C.P. (eds) White cells and platelets in blood transfusion. Developments in Hematology and Immunology, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2089-0_13

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  • DOI: https://doi.org/10.1007/978-1-4613-2089-0_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9238-8

  • Online ISBN: 978-1-4613-2089-0

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