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The Polyoma Enhancer

  • Chapter
Molecular Aspects of Papovaviruses

Part of the book series: Developments in Molecular Virology ((DMVI,volume 9))

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Abstract

We have analyzed the interaction of mouse 3T6 cellular proteins with the polyoma enhancer in vivo and in vitro. Four interacting domains are disclosed corresponding to functional domains defined in vivo. The interaction with the B enhancer domain was analyzed in more detail. Strong base-specific contacts were detected with the early proximal half of the GC-rich palindrome on the late coding strand. A 25 bp region including this sequence is sufficient to provide binding specificity: this region coincides with the core of the B element. The implication of these findings for polyoma enhancer function are discussed.

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Author information

Authors and Affiliations

  1. Department of molecular Biology, Pasteur Institute, 25 rue du Dr. Roux, 75724, Paris Cedex 15, France

    J. Piette, M.-H. Kryszke & M. Yaniv

Authors
  1. J. Piette
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  2. M.-H. Kryszke
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  3. M. Yaniv
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Editor information

Editors and Affiliations

  1. The Weizmann Institute of Science, Rehovot, Israel

    Yosef Aloni

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© 1987 Martinus Nijhoff Publishers

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Piette, J., Kryszke, MH., Yaniv, M. (1987). The Polyoma Enhancer. In: Aloni, Y. (eds) Molecular Aspects of Papovaviruses. Developments in Molecular Virology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2087-6_4

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  • DOI: https://doi.org/10.1007/978-1-4613-2087-6_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9237-1

  • Online ISBN: 978-1-4613-2087-6

  • eBook Packages: Springer Book Archive

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