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The SV40 Early Promoter

  • Chapter
Molecular Aspects of Papovaviruses

Part of the book series: Developments in Molecular Virology ((DMVI,volume 9))

Abstract

The SV40 early promoter consists of the TATA-box, which directs the transcriptional machinery/RNA polymerase to the specific startsites of transcriptional initiation, and the 21-bp repeat region and enhancer, both of which are indispensable for efficient early transcription. Specific sequence motifs in the different promoter elements interact with specific trans-acting transcription factors to form a large nucleoprotein complex at the promoter. It is the coordinate functioning of the various promoter elements and their cognate protein factors which is required to promote transcription.

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Author information

Author notes

  1. M. Zenke

    Present address: European Laboratory of Molecular Biology, Postfach 1022.40, 6900, Heidelberg, Germany

  2. A. Wildeman

    Present address: Dept. of Molecular Biology and Genetics, University of Guelph, Guelph, Ontario, Canada

Authors and Affiliations

  1. Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Faculté de Médecine, Unité 184 de Biologie Moléculaire et de Génie Génétique de l’INSERM, 11, rue Humann, 67085, Strasbourg-Cédex, France

    M. Zenke, A. Wildeman & P. Chambon

Authors
  1. M. Zenke
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  2. A. Wildeman
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  3. P. Chambon
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Editor information

Editors and Affiliations

  1. The Weizmann Institute of Science, Rehovot, Israel

    Yosef Aloni

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© 1987 Martinus Nijhoff Publishers

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Zenke, M., Wildeman, A., Chambon, P. (1987). The SV40 Early Promoter. In: Aloni, Y. (eds) Molecular Aspects of Papovaviruses. Developments in Molecular Virology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2087-6_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2087-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9237-1

  • Online ISBN: 978-1-4613-2087-6

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