Assessment of Neurohormonal Parameters in Congestive Heart Failure: Determination of Sodium and Water Regulation
The term “neurohormonal” has arisen as a simplified means to identify the wide array of chemical mediators of central and peripheral nervous system activity, and a diverse group of structurally different hormones, that mediate a variety of homeostatic mechanisms in man. The importance of these neurohormones in congestive heart failure, is not a recent discovery; their contribution to the pathophysiology of heart failure has been studied over several decades yet these substances have been more aggressively evaluated in the last ten years. This is due primarily to two factors: first, the availability of accurate radioimmunoassay and radioenzymatic techniques, and second, the ability to pharmacologically inhibit a variety of these pathways with relatively specific probes. For instance, the use of Captopril to specifically inhibit the renin angiotensin system has become the paradyme of these inhibitors, providing not only physiologic information, but also a potent new approach to therapy.
KeywordsCongestive Heart Failure Glomerular Filtration Rate Water Retention Renal Blood Flow Diuretic Therapy
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