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Immunocharacterization of the Nuclear Acceptor Sites for the Avian Oviduct Progesterone Receptor

  • A. Goldberger
  • M. Horton
  • T. C. Spelsberg

Abstract

It is well known that steroid hormones, certain vitamins and sterols, enter target cells and bind to specific protein receptors in the cytoplasm or nucleus (1–4). This binding is saturable, high affinity, and steroid specific. Once bound by the steroid, the receptor undergoes chemical/conformation change, termed “activation,” which enables the receptor (as a complex with the steroid) to bind to nuclear acceptor sites on the nuclear chromatin (5,6) or nuclear matrix (7,8). It is generally accepted that the binding of the steroid receptor complex to these nuclear acceptor sites is a prerequisite for the steroid regulation of gene transcription and possibly post-transcriptional events.

Keywords

Ascites Fluid Acceptor Site Chromosomal Protein Nuclear Binding Acceptor Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • A. Goldberger
    • 1
  • M. Horton
    • 1
  • T. C. Spelsberg
    • 1
  1. 1.Department of Biochemistry and Molecular BiologyMayo Clinic and Mayo Graduate School of MedicineRochesterUSA

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