Potassium Citrate Therapy of Nephrolithiasis
Potassium citrate is a new and exciting therapeutic modality introduced in 1985 for the management of a wide variety of stone-forming disorders. It has reawakened interest in the deranged citrate metabolism in nephrolithiasis and in the physicochemical effects of citrate in stone formation. It has substantially expanded our capability for an effective medical control of stone disease. The approval of this drug in the United States represented a culmination of our seven years of extensive laboratory and clinical work. This chapter will review this work pertaining to: (1) physicochemical action of citrate, (2) physiological effect of potassium citrate, (3) physicochemical effect of potassium citrate, (4) long-term clinical trial with potassium citrate and safety of potassium citrate.
KeywordsFatigue Crystallization Phosphorus Citrate Oxalate
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