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Relaxing Action of Muzolimine on Guinea-Pig Isolated Aorta

  • P. Dorigo
  • R. M. Gaion
  • E. Valentini
  • I. Maragno
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Muzolimine, a pyrazolinone derivative (1) with high-ceiling activity (2) and a prolonged action, showed in preliminary studies a diuretic activity similar to that of furosemide (3) together with antihypertensive efficacy (4, 5) similar to the thiazides (6). The aim of the present study was to investigate the influence of muzolimine on vascular smooth muscle and to compare vascular effect induced by muzolimine with those of furosemide whose vasodilatatory action is well known.

Keywords

Prolonged Action Vasodilatatory Action Antihypertensive Efficacy Double Reciprocal Plot Physiological Salt Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • P. Dorigo
    • 1
  • R. M. Gaion
    • 1
  • E. Valentini
    • 1
  • I. Maragno
    • 1
  1. 1.Department of PharmacologyUniversity of PaduaPaduaItaly

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