Inhibition of the Erythrocyte Na+, K+-Pump by Mammalian Lignans: A Possible Link with Endogenous Digitalis
Natural products formed by oxidative dimerization of phenols, most lignans belong to the vegetal world. However, related structures have been found recently in human and animal urines (1,2). These mammalian lignans are characterized by the presence of the meta hydroxyl group on each aryl cycle of a dibenzyl-gamma-butyrolactone framework (Fig. 1, ref 3).
KeywordsOestradiol Glycoside Digoxin Benzyl Lactone
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- 3.Setchel, K.D.R., Lawson, A.M., Conway, E., Taylor, N.F., Kirk, D.N., Cooley, G., Farrant, R.D., Wynn, S. and Axelson, M. Biochem. J. 197: 447–458, 1981a.Google Scholar
- 8.Godfraind, T. and Fagoo, M. (1985) Symposium “Cardiac Glycosides 1785–1985” (Ed. Erdmann) pp 34 (in press).Google Scholar
- 12.Robin, J.P. and Braquet, P. (1986) J. Med. Chem. (in preparation).Google Scholar