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Plasma Levels of Human Atrial Natriuretic Peptide in Chronic Uremic Patients

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Diuretics: Basic, Pharmacological, and Clinical Aspects

Part of the book series: Developments in Nephrology ((DINE,volume 18))

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Abstract

So far, 3 atrial natriuretic polypeptides (ANP) have been isolated from human cardiocytes and, among them, the α-type seems to be preferentially released into the blood stream (1). In normal man, saline infusion or high sodium intake increase plasma α-hANP levels while the opposite is true on low sodium diet (2). These observations seem to suggest that α-hANP is involved in extracellular fluid volume (ECFV) homeostasis. This study was undertaken to obtain some more insight about the involvement of α-hANP in the pathophysiology of body fluid volume in man.

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References

  1. Sugarawa, A., Nakao, K., Morii, N., Sakamoto, M., Suda, M., Shimokura, M., Kiso, Y., Kihara, M., Yamory, Y., Nishimura, K., Soneda, J., Ban, T., Imura, M. Biochem. and Biophys. Res. Comm. 129: 439–446, 1985.

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  2. Sagnella, G.A., Markandu, N.D., Share, A.C., Mc Gregor, G.A. Lancet, ii: 1208–1211, 1985.

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  3. Sagnella, G.A., Mac Gregor, G.A. Nature, 309: 666–667, 1984.

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© 1987 Martinus Nijhoff Publishing, Boston

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Cannella, G. et al. (1987). Plasma Levels of Human Atrial Natriuretic Peptide in Chronic Uremic Patients. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_38

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  • DOI: https://doi.org/10.1007/978-1-4613-2067-8_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9227-2

  • Online ISBN: 978-1-4613-2067-8

  • eBook Packages: Springer Book Archive

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