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Diuretics: Basic, Pharmacological, and Clinical Aspects pp 140–144Cite as

Salt Loading in Spontaneously Hypertensive Rats Further Elevates Blood Pressure Despite Enhanced Release of Atrial Natriuretic Peptides and Exaggerated Natriuresis

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Part of the book series: Developments in Nephrology ((DINE,volume 18))

Abstract

It has been suggested but not established that atrial natriuretic peptides (ANP) may have a role in the mechanisms of hypertension and associated exaggerated natriuresis during volume expansion. The present investigation was undertaken to examine the influence of chronic salt loading on the circulating plasma levels of ANP in spontaneously hypertensive rats (SHR) and to study the concomitant changes in blood pressure as well as urinary excretion of sodium. Normotensive Wistar Kyoto (WKY) rats were studied as controls under the same protocol.

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References

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Author information

Authors and Affiliations

  1. Hypertension Division, Department of Medicine, Sepulveda VA Medical Center, University of California at Los Angeles, CA, 91343, USA

    M. Sambhi, M. Kohno & K. Clegg

Authors
  1. M. Sambhi
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  2. M. Kohno
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  3. K. Clegg
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Editor information

Editors and Affiliations

  1. Department of Nephrology, University of Naples, Naples, Italy

    V. E. Andreucci M.D.  & Antonio Dal Canton M.D.  & 

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© 1987 Martinus Nijhoff Publishing, Boston

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Sambhi, M., Kohno, M., Clegg, K. (1987). Salt Loading in Spontaneously Hypertensive Rats Further Elevates Blood Pressure Despite Enhanced Release of Atrial Natriuretic Peptides and Exaggerated Natriuresis. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_34

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  • DOI: https://doi.org/10.1007/978-1-4613-2067-8_34

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9227-2

  • Online ISBN: 978-1-4613-2067-8

  • eBook Packages: Springer Book Archive

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