Atrial Natriuretic Peptide Raise Hematocrit in Conscious Nephrectomized Rats
In 1981, De Bold and coworkers demonstrated that extracts originating from rat cardiac atria exert a diuretic and natriuretic effect when injected into rats. They also des-cribed a concomitant rise in hematocrit (1). It now appears that the rise in hematocrit induced by atrial natriuretic peptide (ANP) contained in atrial extracts cannot be fully explained by renal losses of water and electrolytes (2,3). In addition, preliminary in vitro studies carried out in our laboratory have shown that ANP does not modify hematocrit by increasing erytrocyte volume.
KeywordsAtrial Natriuretic Peptide Blood Pressure Lowering Prostaglandin Synthesis Vascular Compartment Blood Pressure Lowering Effect
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