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Atrial Natriuretic Peptide Raise Hematocrit in Conscious Nephrectomized Rats

  • J. P. Fluckiger
  • B. Waeber
  • G. Matsueda
  • J. Nussberger
  • H. R. Brunner
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

In 1981, De Bold and coworkers demonstrated that extracts originating from rat cardiac atria exert a diuretic and natriuretic effect when injected into rats. They also des-cribed a concomitant rise in hematocrit (1). It now appears that the rise in hematocrit induced by atrial natriuretic peptide (ANP) contained in atrial extracts cannot be fully explained by renal losses of water and electrolytes (2,3). In addition, preliminary in vitro studies carried out in our laboratory have shown that ANP does not modify hematocrit by increasing erytrocyte volume.

Keywords

Atrial Natriuretic Peptide Blood Pressure Lowering Prostaglandin Synthesis Vascular Compartment Blood Pressure Lowering Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    De Bold, A.J., Borenstein, H.B., Veres, A.T., and Sonnenberg, H. Life Sci. 28: 89–94, 1981.PubMedCrossRefGoogle Scholar
  2. 2.
    Biollaz, J., Nussberger, J., Waeber, B., and Brunner, H.R. J. of Hypert. 1986 (In press).Google Scholar
  3. 3.
    Flückiger, J.P., Waeber, B., Matsueda, G., Nussberger, J., Brunner, H.R. Am. J. Physiol. 1986 (In press).Google Scholar
  4. 4.
    Waeber, B., Matsueda, G. Aubert, J.F., Nussberger J. and Brunner, H.R. Eur. J. Pharmacol. 1986 (In press).Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • J. P. Fluckiger
    • 1
  • B. Waeber
    • 1
  • G. Matsueda
    • 1
  • J. Nussberger
    • 1
  • H. R. Brunner
    • 1
  1. 1.Division of HypertensionUniversity HospitalLausanneSwitzerland

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