Abstract
Cicletanide is a new antihypertensive agent with diuretic properties which have been postulated to rely partly upon the stimulation of the renal synthesis of prostacycline (1–2). In the present work, the kinetics as well as the effects of a single oral dose of cicletanine on the urinary excretion of electrolytes and of the metabolites of prostacycline and thromboxane A2 were determined in patients with varying degrees of renal function.
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© 1987 Martinus Nijhoff Publishing, Boston
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Goeffroy, J. et al. (1987). Influence of Renal Insufficiency on the Pharmacokinetics and the Renal Effects of Cicletanine. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_27
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DOI: https://doi.org/10.1007/978-1-4613-2067-8_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9227-2
Online ISBN: 978-1-4613-2067-8
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