Modification in Renal Handling of Phosphate Induced by Hydrochlorothiazide (HCTZ) and Amiloride (A)
Hydrochlorothiazide (HCTZ) has long been known as an effective hypocalciuric agent (1–3). When associated with amiloride, which has been shown to have hypocalciuric effect similar to that of thiazide (4), it may effectively reduce urine calcium excretion at dosages which are lower than those required by the single administration of each drug (5). For these reasons the combination of HCTZ and A has been widely used in patients with recurrent calcium nephrolithiasis (RCN). However, the mechanisms by which HCTZ and A act on the renal tubules are far from being clearly established and it is not known whether this drug combination may affect transport system other than those for sodium and calcium.
KeywordsHyperparathyroidism Hydrochlorothiazide Thiazide Amiloride Nephrolithiasis
Unable to display preview. Download preview PDF.