Abstract
The loop diuretic furosemide (*Fur) exerts its major diuretic effect by inhibiting NaCl reabsorption in the thick ascending limb of Henle. However, many studies have suggested an additional effect of Fur on proximal tubular Na reabsorption, in particular when care was taken to minimize changes in renal hemodynamics due to diuretic-induced volume contraction (1). Very little is known about the dose dependence of the proximal effect of Fur, so this was investigated by clearance technique in conscious rats, using the renal lithium clearance as a measure for the delivery of Na out of the proximal tubule (2).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Abbreviations
- Fur:
-
furosemide;
- GFR:
-
filtration rate;
- C:
-
clearance;
- U:
-
urine concentration;
- V:
-
urine volume;
- FE:
-
fractional excretion;
References
Seely, J.F., Dirks, J.H. Kidney Int. 11: 1–8, 1977.
Thomsen, K. Nephron 37: 217–223, 1984.
Goldberg, M. In: Hand book of Physiology, Sect. 8: Renal Physiology (Eds. J. Orloff, R.W. Berliner and S.R. Geiger) Waverly Press, Baltimore 1973, pp. 1003-1031.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Christensen, S., Petersen, J.S., Steiness, E., Andreasen, F. (1987). Dose Dependence of Inhibition of Proximal Tubular Sodium Reabsorption by Furosemide in Conscious Rats. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_20
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2067-8_20
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9227-2
Online ISBN: 978-1-4613-2067-8
eBook Packages: Springer Book Archive