Abstract
The mechanisms of the calciuretic effect of furosemide was investigated in the diluting segment with electrophysiological methods. Furosemide completely inhibited Ca-reabsorption and reduced transepithelial voltage to zero. Ca-reabsorption revealed a linear voltage dependence. Nifedipine failed to block a transcellular route of Ca-reabsorption. From these data we conclude that Ca-reabsorption occurs paracellularly and furosemide reduces its electrical driving force.
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© 1987 Martinus Nijhoff Publishing, Boston
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Dietl, P., Oberleithner, H. (1987). Voltage-Driven Calcium Reabsorption in Diluting Segment: INHIBITION by Furosemide but Not by Calcium Antagonists. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_18
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DOI: https://doi.org/10.1007/978-1-4613-2067-8_18
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