Natriuretic Potency of Various Diuretics

  • A. J. Reyes
  • W. P. Leary
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Single doses of various commonly used diuretic formulations and of placebo were randomly and double blind administered to healthy volunteers kept in a metabolic ward. All studied formulations increased mean 24-hr natriuresis significantly. Early distal tubular diuretics elevated urinary Na+ flow over the 24-hr period that followed medication; loop-diuretic formulations raised urinary Na+ output strikingly in the 0–3-hr period after dosing, but invariably caused an undershoot in urinary Na+ flow in the 6–24-hr post-dosing interval. As a consequence, loop diuretics induced lower increases in mean 24-hr urinary Na+ output than early distal tubular substances. When monodoses are given to healthy individuals, loop-diuretic formulations in current use generally elicit lower 24-hr natriuretic effects than commonly employed early distal tubular diuretic formulations.

Keywords

Placebo Procardias Furosemide Hydrochlorothiazide Amiloride 

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References

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    Reyes, A.J. and Leary, W.P. Curr. Ther. Res. 30: 227–235, 1981.Google Scholar
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    Roberts, C.J.C. and Daneshmend, T.K. Br. J. Clin. Pharmacol. 12: 465–474, 1981.PubMedGoogle Scholar
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    Hamdy, R.C., Vinson, M., Robbins, A.D., Struthers, L.P.L., Chapman, S.F., Norris, R.J. and Shaw, H.L. In: Diuretics (Ed. J.B. Puschett), Elsevier, New York Amsterdam Oxford, 1984, pp. 403–406.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • A. J. Reyes
    • 1
  • W. P. Leary
    • 2
  1. 1.Departamento de Investigación CardiovascularFundación ProcardiasMontevideoUruguay
  2. 2.Department of Experimental and Clinical PharmacologyUniversity of NatalDurbanSouth Africa

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