Abstract
Single doses of various commonly used diuretic formulations and of placebo were randomly and double blind administered to healthy volunteers kept in a metabolic ward. All studied formulations increased mean 24-hr natriuresis significantly. Early distal tubular diuretics elevated urinary Na+ flow over the 24-hr period that followed medication; loop-diuretic formulations raised urinary Na+ output strikingly in the 0–3-hr period after dosing, but invariably caused an undershoot in urinary Na+ flow in the 6–24-hr post-dosing interval. As a consequence, loop diuretics induced lower increases in mean 24-hr urinary Na+ output than early distal tubular substances. When monodoses are given to healthy individuals, loop-diuretic formulations in current use generally elicit lower 24-hr natriuretic effects than commonly employed early distal tubular diuretic formulations.
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References
Reyes, A.J. and Leary, W.P. Curr. Ther. Res. 30: 227–235, 1981.
Roberts, C.J.C. and Daneshmend, T.K. Br. J. Clin. Pharmacol. 12: 465–474, 1981.
Hamdy, R.C., Vinson, M., Robbins, A.D., Struthers, L.P.L., Chapman, S.F., Norris, R.J. and Shaw, H.L. In: Diuretics (Ed. J.B. Puschett), Elsevier, New York Amsterdam Oxford, 1984, pp. 403–406.
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© 1987 Martinus Nijhoff Publishing, Boston
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Reyes, A.J., Leary, W.P. (1987). Natriuretic Potency of Various Diuretics. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_129
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DOI: https://doi.org/10.1007/978-1-4613-2067-8_129
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