Effects of Muzolimine on Free-Water Excretion in Edematous and Hyponatremic Patients
Muzolimine (M) is a new Henle’s loop diuretic with no structural similarity to currently available diuretics. M is characterized by high-ceiling activity, long duration of action and absence of the ‘rebound phenomenon’ (1) and therefore may be more advantageous than the other diuretics in the treatment of renal, cardiac or epatic edema, generally associated with antidiuresis and hyponatremia. Several reports of life-threatening hyponatremia associated with thiazide administration have recently appeared in the literature (2, 3). The administration of Henle’s loop diuretic may, in fact, impair the capacity to excrete dilute urine by inhibiting NaCl reabsorption in the distal diluting segments. Yet, the effect of M on free-water excretion has not been investigated in edematous patients with hyponatremia.
KeywordsCreatinine Prostaglandin Thiazide Muzolimine
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