Effects of Muzolimine on Free-Water Excretion in Edematous and Hyponatremic Patients
Muzolimine (M) is a new Henle’s loop diuretic with no structural similarity to currently available diuretics. M is characterized by high-ceiling activity, long duration of action and absence of the ‘rebound phenomenon’ (1) and therefore may be more advantageous than the other diuretics in the treatment of renal, cardiac or epatic edema, generally associated with antidiuresis and hyponatremia. Several reports of life-threatening hyponatremia associated with thiazide administration have recently appeared in the literature (2, 3). The administration of Henle’s loop diuretic may, in fact, impair the capacity to excrete dilute urine by inhibiting NaCl reabsorption in the distal diluting segments. Yet, the effect of M on free-water excretion has not been investigated in edematous patients with hyponatremia.
KeywordsUrinary Osmolality Urinary Sodium Excretion Serum Sodium Concentration Rebound Phenomenon Clearance Period
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- 4.Berg K.J., Jorstad S., Tromsdal A.: ‘Studies on the clinical pharmacology of a new potent diuretic, Bay g 2821’. Pharmatherapeutica 1: 319–321, 1972.Google Scholar
- 5.Bandiera F., Dessi-Fulgheri P., Madeddu P., Cocco F., Oppes M., Glorioso N., Spanedda M., Rappelli A.: ‘Role of renal prostaglandins in mediating the activity of muzolimine’. Proceedings of the International Meeting on Diuretics. Sorrento, 1986. In press. Martinus Nijhoff Publ. Andreucci V.E. and Dal Canton A. Ed. 1986.Google Scholar