Abstract
Muzolimine (M) is a new Henle’s loop diuretic with no structural similarity to currently available diuretics. M is characterized by high-ceiling activity, long duration of action and absence of the ‘rebound phenomenon’ (1) and therefore may be more advantageous than the other diuretics in the treatment of renal, cardiac or epatic edema, generally associated with antidiuresis and hyponatremia. Several reports of life-threatening hyponatremia associated with thiazide administration have recently appeared in the literature (2, 3). The administration of Henle’s loop diuretic may, in fact, impair the capacity to excrete dilute urine by inhibiting NaCl reabsorption in the distal diluting segments. Yet, the effect of M on free-water excretion has not been investigated in edematous patients with hyponatremia.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Dal Canton A., Russo D., Gallo R., Conte G., Andreucci V.E. ‘Muzolimine: a new high-ceiling diuretic suitable for patients with advanced renal disease’. Brit. Med. J. 282: 595–598, 1981.
Ayus J.C., Olivero J.J. and Frammer J.P.: ‘Rapid correction of severe hyponatremia with intravenous hypertonic saline solution’. Am. J. Med. 72: 43–48, 1982.
Ashraf N., Locksley R. and Arieff A.I.: ‘Thiazide-induced hyponatremia with death or neurological damage in outpatients’. Am. J. Med. 70: 1163–1168, 1981.
Berg K.J., Jorstad S., Tromsdal A.: ‘Studies on the clinical pharmacology of a new potent diuretic, Bay g 2821’. Pharmatherapeutica 1: 319–321, 1972.
Bandiera F., Dessi-Fulgheri P., Madeddu P., Cocco F., Oppes M., Glorioso N., Spanedda M., Rappelli A.: ‘Role of renal prostaglandins in mediating the activity of muzolimine’. Proceedings of the International Meeting on Diuretics. Sorrento, 1986. In press. Martinus Nijhoff Publ. Andreucci V.E. and Dal Canton A. Ed. 1986.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Conte, G. et al. (1987). Effects of Muzolimine on Free-Water Excretion in Edematous and Hyponatremic Patients. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_119
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2067-8_119
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9227-2
Online ISBN: 978-1-4613-2067-8
eBook Packages: Springer Book Archive