Favourable Effects of Muzolimine on Urea Plasma Levels in Chronic Renal Failure

  • F. Mastrangelo
  • M. Napoli
  • C. Corliano’
  • V. De Blasi
  • S. Rizzelli
  • L. Alfonso
  • A. M. Montinaro
  • M. Aprile
  • P. Patruno
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

In chronic uremia a diuresis of more than 2 ml/min has been generally-considered to be of little value regarding to urea elimination (1). In previous studies (2) we found that the combination of diuretic and reinfusion measures may lead to a rather quick decrease in blood urea in some pts with GFR of less than 20 ml/min. An inverse relation between blood urea and diuresis during treatment with Muzolimine was seen. To clarify this phenomenon, the urea excretion studies were performed in non oedematous pts with advanced CFR. The pts were treated by Muzolimine (240 mg) and saline infusion, in order to avoid the “braking phenomenon” (3) and the depletion of Extracellu lar Fluid Volume.

Keywords

Urea Creatinine Convolution Stein Uremia 

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References

  1. 1.
    Reubi, F. Intern. Symp. Fealdafing. Springer Verlag Berlin 1969, p.381.Google Scholar
  2. 2.
    Mastrangelo, F. et al. Z. Kardiol. 74, Suppl. 2: 109–114, 1985.PubMedGoogle Scholar
  3. 3.
    Grantham, J.J. and Chonco, A.M. In: Sodium and Water Homeostasis (Eds B.M. Brenner and J.H. Stein), Churchill Livingstone, N.Y. 1978, p. 178.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • F. Mastrangelo
    • 1
  • M. Napoli
    • 1
  • C. Corliano’
    • 1
  • V. De Blasi
    • 1
  • S. Rizzelli
    • 1
  • L. Alfonso
    • 1
  • A. M. Montinaro
    • 1
  • M. Aprile
    • 1
  • P. Patruno
    • 1
  1. 1.Department of Nephrology and Dialysis“V. Fazzi” HospitalLecceItaly

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