Abstract
Scheinker (1938) reported a 39-year-old man with a progressive sensorimotor neuropathy beginning in the legs. The patient had a solitary plasmacytoma of the sternum and two large areas of thickened, deeply pigmented skin on the anterior chest wall. The cerebrospinal fluid protein level was elevated, but the nervous system was not directly involved by the plasmacytoma. Crow (1956) described two patients with peripheral neuropathy and myeloma. One had a destructive lesion in the scapula with sclerotic margins and involvement of adjacent nodes, while the other had a destructive lesion in the sternum with new bone formation and involvement of the mediastinum. Biopsy of the tumors revealed plasmacytomas. The cerebrospinal fluid protein was elevated in both cases, and both had cutaneous hyperpigmentation. Peripheral neuropathy was reported in three cases of typical multiple myeloma, but in two additional cases features of myeloma were atypical in that hyperglobulinemia, Bence Jones proteinuria, and plasma cell infiltration of the sternal marrow were absent. In addition, symptoms of polyneuropathy dominated the clinical picture and, in one case, osteoblastic lesions were seen (Victor et al., 1958). The authors emphasized that the myelomatous lesions did not directly involve the nervous system and that the polyneuropathies were similar to carcinomatous neuropathy. In an excellent report, Morley and Schwieger (1967) reviewed 23 cases from the literature with osteosclerotic myeloma and peripheral neuropathy and added four more of their own.
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© 1987 Martinus Nijhoff Publishing, Boston
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Kyle, R.A. (1987). Osteosclerotic Myeloma. In: Polyneuropathies Associated with Plasma Cell Dyscrasias. Topics in the Neurosciences, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2065-4_7
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DOI: https://doi.org/10.1007/978-1-4613-2065-4_7
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