Skip to main content
SpringerLink
Log in

Multiple Myeloma

  • Chapter
Polyneuropathies Associated with Plasma Cell Dyscrasias

Part of the book series: Topics in the Neurosciences ((TNSC,volume 5))

  • 36 Accesses

Abstract

Although neurologic manifestations of myeloma most commonly affect the spinal cord, peripheral neuromuscular symptoms are uncommon. The first report of peripheral nerve involvement in myeloma was probably that of Davison and Balser (1937) who reviewed the neurologic complications of multiple myeloma. Scheinker subsequently (1938) reported a pathological and clinical study of a case of polyneuropathy and a solitary sternal plasmacytoma, probably osteosclerotic. Additional reports followed by Crow (1956), Odelberg-Johnson (1959), Victor et al. (1958), Small et al. (1961), Rohmer et al. (1962), Aguayo (1964), Gupta and Prabhash (1965), and Rushton (1965) describing cases of myeloma and solitary myeloma (often with osteosclerotic features) with associated polyneuropathy. These patients presented with a variety of clinical syndromes ranging from a “Guillain-Barre-like” syndrome (Odelberg-Johnson, 1959) to a pure sensory neuropathy (Victor et al., 1958). Thus, early on it became apparent that the polyneuropathy associated with myeloma was complex and included patients with different types of myeloma (multiple myeloma-lytic type, solitary plasmacytoma, and osteosclerotic myeloma) and with different neurologic presentations within and between groups. In addition, although amyloidosis (AL) was known to occur in myeloma (Kyle and Bayrd, 1975), it was not recognized as a cause of polyneuropathy. In an influential paper, Victor et al. (1958) found mostly demyelination on histopathologic study of their five patients and no evidence of amyloid deposition, and they thus concluded that amyloid played no part in myeloma polyneuropathy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aguayo A, Thompson DW, Humphrey JG: Multiple myeloma with polyneuropathy and osteosclerotic lesions. J Neurol Neurosurg Psychiatry 27:562–566, 1964.

    Article  PubMed  CAS  Google Scholar 

  2. Asbury AK, Johnson PC: Pathology of Peripheral Nerve: Major Problems in Pathology (vol 7). Philadelphia: WB Saunders, p 148–155, 1978.

    Google Scholar 

  3. Bardwick PA, Zvaifler NJ, Gill GN, et al: Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes: The POEMS syndrome. Medicine (Baltimore) 59:311–22, 1980.

    CAS  Google Scholar 

  4. Barron KD, Rowland LP, Zimmerman HM: Neuropathy with malignant tumor metastases. J Nerv Ment Dis 181:10–31, 1960.

    Google Scholar 

  5. Besinger UA, Toyka KV, Anzil AP, et al: Myeloma neuropathy: Passive transfer from man to mouse. Science 213:1027–1030, 1981.

    Article  PubMed  CAS  Google Scholar 

  6. Borges LF, Busis NA: Intraneuronal accumulation of myeloma proteins. Arch Neurol 42: 690–694, 1985.

    PubMed  CAS  Google Scholar 

  7. Carrier H, Guilland-Barbaret C, Chazot G, et al: Les neuropathies des gammopathies monoclonales. Acta Neuropathol (Bed) 44:77–81, 1978.

    Article  CAS  Google Scholar 

  8. Case records of the Massachusetts General Hospital, Case #24–1977: New Engl J Med 296:1399–1405, 1977.

    Article  Google Scholar 

  9. Case records of the Massachusetts General Hospital, Case #31–1977: New England J Med 297:266–274, 1977.

    Article  Google Scholar 

  10. Croft PB, Urich H, Wilkinson M: Peripheral neuropathy of sensory motor type associated with malignant disease. Brain 90:31–66, 1967.

    Article  PubMed  CAS  Google Scholar 

  11. Crow RS: Peripheral neuritis in myelomatosis. Br Med J 2:802–804, 1956.

    Article  PubMed  CAS  Google Scholar 

  12. Currie S, Henson RA, Morgan HG, et al: The incidence of nonmetastatic neurological syndromes of obscure origin in the reticuloses. Brain 93:629–640, 1970.

    Article  PubMed  CAS  Google Scholar 

  13. Davies-Jones GAB, Esiri MM: Neuropathy due to amyloid in myelomatosis. Br Med J 2:444, 1971.

    Article  PubMed  CAS  Google Scholar 

  14. Davis LE, Drachman DB: Myeloma neuropathy: Successful treatment of two patients and review of cases. Arch Neurol 27:507–511, 1972.

    PubMed  CAS  Google Scholar 

  15. Davison C, Balser BH: Myeloma and its neural complications, Arch Surg 35:913–936, 1937.

    Google Scholar 

  16. Davidson S: Solitary myeloma with peripheral neuropathy — recovery after treatment. Calif Med 116:68–71, 1972.

    PubMed  CAS  Google Scholar 

  17. Dayan AD, Urich H, Gardner-Thorpe C: Peripheral neuropathy and myeloma. J Neurol Sci 14:21–35, 1971.

    Article  PubMed  CAS  Google Scholar 

  18. Denny-Brown D: Primary sensory neuropathy with muscular changes associated with carcinoma. J Neurol Neurosurg Psychiatry 11:73–87, 1948.

    Article  PubMed  CAS  Google Scholar 

  19. Driedger H, Pruzanski W: Plasma cell neoplasm with osteosclerotic lesions: A study of five cases and a review of the literature. Arch Intern Med 139:892–896, 1979.

    Article  PubMed  CAS  Google Scholar 

  20. Dayan AD, Stokes MI: Peripheral neuropathy and experimental myeloma in the mouse. Nature 236:117–118, 1972.

    Article  CAS  Google Scholar 

  21. Dyck PJ: Pathologic alterations of the peripheral nervous system in man. In: Peripheral Neuropathy (vol 1), PJ Dyck, PK Thomas, EH Lambert, RI Bunge (eds). Philadelphia: WB Saunders, 1984.

    Google Scholar 

  22. Dyck PJ, Lais AC, Ohta M, et al: Chronic inflammatory polyradiculopathies. Mayo Clin Proc 50:621–637, 1975.

    PubMed  CAS  Google Scholar 

  23. Evison G, Evans KT: Bone sclerosis in multiple myeloma. Br J Radiol 40:81–89, 1967.

    Article  PubMed  CAS  Google Scholar 

  24. Gupta SP, Prabhash BR: Peripheral neuropathy and solitary myeloma (letter to the editor). Br Med J 2:203–205, 1965.

    Article  Google Scholar 

  25. Hesselvik M: Neuropathological studies on myelomatosis. Acta Neurol Scand 45:95–108, 1969.

    Article  PubMed  CAS  Google Scholar 

  26. Hineman VL, Phyliky RL, Banks PM: Angiofollicular lymph node hyperplasia and peripheral neuropathy: Association with monoclonal gammopathy. Mayo Clin Proc 57:379–382, 1982.

    PubMed  CAS  Google Scholar 

  27. Horwich MS, Cho L, Porro RS, et al: Subacute sensory neuropathy: A remote effect of carcinoma. Ann Neurol 2:7–19, 1977.

    Article  PubMed  CAS  Google Scholar 

  28. Kelly JJ Jr, Kyle RA, O’Brien PC, et al: The natural history of peripheral neuropathy in primary systemic amyloidosis. Ann Neurol 6:1–7, 1979.

    Article  PubMed  Google Scholar 

  29. Kelly JJ Jr, Kyle RA, O’Brien PC, et al: Prevalence of monoclonal protein in peripheral neuropathy. Neurology (NY) 31:1480–1483, 1981.

    Google Scholar 

  30. Kelly JJ Jr: The electrodiagnostic findings in peripheral neuropathies associated with monoclonal gammopathies. Muscle & Nerve 6:504–509, 1983.

    Article  Google Scholar 

  31. Kelly JJ Jr, Kyle RA, Miles JM, Dyck PJ: Osteosclerotic myeloma and peripheral neuropathy. Neurology (NY) 33: 202–210, 1983.

    Google Scholar 

  32. Kelly JJ Jr, Kyle RA, Miles JM, et al: The spectrum of peripheral neuropathy in myeloma. Neurology (NY) 31:24–31, 1981.

    Google Scholar 

  33. Kyle RA: Multiple myeloma; review of 869 cases. Mayo Clin Proc 50:29–40, 1975.

    PubMed  CAS  Google Scholar 

  34. Kyle RA, Bayrd ED: Amyloidosis: Review of 236 cases. Medicine (Baltimore) 54:271–299, 1975.

    CAS  Google Scholar 

  35. Kyle RA, Nobrega FT, Kurland LT: Multiple myeloma in Olmsted County, Minnesota, 1945–1964. Blood 33:739–745, 1969.

    PubMed  CAS  Google Scholar 

  36. Lisak RP, Zweiman B, Mitchell M, et al. Guillain-Barre syndrome and Hodgkin’s disease: Three cases with immunologic studies. Ann Neurol 1:72, 1977.

    Article  PubMed  CAS  Google Scholar 

  37. Lowbeer L: Multiple myeloma with osteosclerosis (Abstr) Am J Clinic Pathol 52:757, 1969.

    Google Scholar 

  38. Nakanishi T, Sobue I, Toyokura Y, et al: The Crow-Fukase syndrome: A study of 102 cases in Japan. Neurology (Cleveland) 34:712–720, 1984.

    CAS  Google Scholar 

  39. Nathanson L, Schiller AL: Case records of the Massachusetts General Hospital. N Engl J Med 287:138–143, 1972.

    Article  Google Scholar 

  40. Neundorfer B, Meyer JG, Volk B: Amyloid neuropathy due to monoclonal gammopathy: A case report. J Neurol 216:207–215, 1977

    Article  PubMed  CAS  Google Scholar 

  41. Odelberg-Johnson O: Osteosclerotic changes in myelomatosis: Report of a case. Acta Radiol 52:139–144, 1959.

    Article  PubMed  CAS  Google Scholar 

  42. Ohi T, Kyle RA, Dyck PJ: Axonal attenuation and secondary segmental demyelination in myeloma neuropathies. Ann Neurol 17:255–261, 1985.

    Article  PubMed  CAS  Google Scholar 

  43. Pellegrini G, Scarlato G, Maggio M, et al: Sensorimotor polyneuropathy in light-chain multiple myeloma. Acta Neuropathol (Berl) suppl VII:255–257, 1981.

    Google Scholar 

  44. Read D, Warlow C: Peripheral neuropathy and solitary plasmacytoma. J Neurol Neurosurg Psychiatry 41: 177–184, 1978.

    Article  PubMed  CAS  Google Scholar 

  45. Rohmer F, Mengus M, Buchheit F: Neuropathie paraneoplastique a type de syndrome di Guillain-Barre chez un malade atteint de myelome solitarie. Revue D’Oto-Neuro-Opthalmologie 34:97–107, 1962.

    CAS  Google Scholar 

  46. Rushton DI: Peripheral sensorimotor neuropathy associated with a localized myeloma. Br Med J 2:203–205, 1965.

    Article  PubMed  CAS  Google Scholar 

  47. Scheinker I: Myelom und Nervensystem. Dtsch Z Nervenheilk 147:247–273, 1938.

    Article  Google Scholar 

  48. Sherman WH, Olarte MR, McKiernan G, et al: Plasma exchange treatment of peripheral neuropathy associated with plasma cell dyscrasia. J Neurol Neurosurg Psychiatry 47:813–819, 1984.

    Article  PubMed  CAS  Google Scholar 

  49. Silverstein A, Doniger DE: Neurologic complication of myelomatosis. Arch Neurol 9:534–544, 1963.

    PubMed  CAS  Google Scholar 

  50. Small JM, Moxon CP, Wolff AL: Myelomatous neuropathy. Birmingham Medical Rev 20:546–552, 1961.

    Google Scholar 

  51. Takatsuki K, Sanada I: Plasma cell dyscrasia with polyneuropathy and endocrine disorder: Clinical and laboratory features of 109 reported cases. Jpn J Clin Oncol 13:543–556, 1983.

    PubMed  CAS  Google Scholar 

  52. Verghese JP, Bradley WC, Nemni R, McAdam PWJ: Amyloid neuropathy in multiple myeloma and other plasma cell dyscrasias: A hypothesis of the pathogenesis of amyloid neuropathies. J Neurol Sci 59:237–246, 1983.

    Article  PubMed  CAS  Google Scholar 

  53. Victor M, Banker BQ, Adams RD: The neuropathy of multiple myeloma. J Neurol Neurosurg Psychiatry 21:73–88, 1958.

    Article  PubMed  CAS  Google Scholar 

  54. Vital C, Lacoste D, Deminiere C, et al: Amyloid neuropathy and multiple myeloma: Ultrastructural and immunopathological study of two cases. Eur Neurol 22:106–112, 1983.

    Article  PubMed  CAS  Google Scholar 

  55. Waldenstrom JG, Adner A, Gydell K, et al: Osteosclerotic “plasmacytoma” with polyneuropathy, hypertrichosis, and diabetes. Acta Med Scand 203:297–303, 1978.

    Article  PubMed  CAS  Google Scholar 

  56. Walsh JC: The neuropathy of multiple myeloma. Arch Neurol 25:404–414, 1971.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Electromyography Laboratory, Department of Neurology, Tufts-New England Medical Center, 02111, Boston, MA, USA

    John J. Kelly Jr. M.D. (Associate Professor of Neurology Director)

Authors
  1. John J. Kelly Jr. M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Kelly, J.J. (1987). Multiple Myeloma. In: Polyneuropathies Associated with Plasma Cell Dyscrasias. Topics in the Neurosciences, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2065-4_6

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2065-4_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9226-5

  • Online ISBN: 978-1-4613-2065-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation