Abstract
Sotalol is a beta-adrenoreceptor blocking agent (nonselective and devoid of membrane-stabilizing or intrinsic sympathomimetic activities) which has also class 3 antiarrhythmic properties. It is effective in angina pectoris, hypertension, and arrhythmias, and reduces the incidence of reinfarctions, but not mortality, in patients with a history of myocardial infarction.
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References
Touboul P, et al: Clinical electrophysiology of intravenous sotalol, a beta-blocking drug with class III antiarrhythmic properties. Am Heart J 107:888, 1984.
Senges J, et al: Electrophysiologic testing in assessment of therapy with sotalol for sustained ventricular tachycardia. Circulation 69:577, 1984.
Klaus-Peter K, et al: Acute and chronic electrophysiologic effects of sotalol in patients with Wolff-Parkinson-White syndrome. AHA, 1983.
McKibbin JK, et al: Sotalol, hypokalaemia, syncope, and torsade de pointes. Br Heart J 51:157, 1984.
Prakash R, et al: Effect of sotalol on clinical arrhythmias. Am J Cardiol 29:397, 1972.
Burckhardt D, et al: Replacement of amiodarone by sotalol for repetitive ventricular premature beats. Am Heart J 107:167, 1984.
Julian DG, et al: Controlled trial of sotalol for one year after myocardial infarction. Lancet: 1142, 1982.
Arstila M, Sundquist M: Dosage of sotalol in the treatment of hypertension. In: Snart AG (ed) Advances in beta-adrenergic blocking therapy: sotalol. Excerpta Medica, Amsterdam, 1976, p 59.
Berglund G, et al: Pharmacokinetics of sotalol after chronic administration to patients with renal insufficiency. Eur J Clin Pharmacol 18:321, 1980.
Anttila M, et al: Human pharmacokinetics of sotalol. Acta Pharmacol Toxicol 39:118, 1976.
Sotaniemi EA, et al: Plasma clearance of propranolol and sotalol and heptaic drugmetabolizing enzyme activity. Clin Pharmacol Ther 26:153, 1979.
Blair AD, et al: Sotalol kinetics in renal insufficiency. Clin Pharmacol Ther 29:457, 1981.
Laakso M, et al: Sotalol, prolonged QT interval and ventricular tachyarrhythmias. Ann Clin Res 13:439, 1981.
Elonen E, et al: Sotalol intoxication with prolonged QT interval and severe tachyarrhythmias [letter]. Br Med J 1:1184, 1979.
Neuvonen PH, et al: Prolonged QT interval and severe tachyarrhythmias: common features of sotalol intoxication. Eur J Clin Pharmacol 20:85, 1981.
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© 1988 Martinus Nijhoff Publishing, Boston
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Schneeweiss, A., Schettler, G. (1988). Sotalol. In: Cardiovascular Drug Therapy in the Elderly. Developments in Cardiovascular Medicine, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2063-0_41
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DOI: https://doi.org/10.1007/978-1-4613-2063-0_41
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9225-8
Online ISBN: 978-1-4613-2063-0
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