Abstract
Ethmozine is the ethyl ester hydrochloride of 1-(3-morpholinopropionyl)-phenothiazine-2-carbonic acid. It was synthetized in 1964 at the Pharmacology Institute of the USSR Academy of Medical Sciences. It has class 1 antiarrhythmic properties, and was found to abolish a variety of both ventricular and supraventricular arrhythmias.
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References
Rosenshtraukh LV, et al: Effects of ethmozine on the contractile force, transmembrane action potential, and sodium current in frog auricular muscle. In: Proceedings USA-USSR first joint symposium on sudden death, Yalta, USSR, 3–5 October 1977. US Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, DHEW Publication, Washington DC, 1977, 291.
Rosenshtraukh LV, et al: Decrease in fast inward sodium current as a possible cause of the antiarrhythmic effect of ethmozin, mexitil and lidocaine in the late stage of experimental myocardial infarction. In: Proceedings USA-USSR second joint symposium, Indianapolis, 1979. US Department of Health and Human Services, Public Health Service, National Institutes of Health, Washington DC, 1979, 119.
Ruffy R, et al: Electrophysiologic effects of ethmozin on canine acute myocardium. Cardio-vasc Res 13:354, 1979.
Rosenshtraukh LV, et al: Effect of ethmozin on ventricular disturbance of rhythm during early and late phases of myocardial infarction. Vestn Akad Med Nauk SSSR 10:52, 1978.
Chazov EI, et al: Ethmozin. I. Effects of intravenous drug administration on paroxysmal supraventricular tachycardia in the ventricular preexcitation syndrome. Am Heart J 108:475, 1984.
Calvo R, et al: Electrophysiologic effects, efficacy and safety of oral moricizine hydrochloride in sustained ventricular tachycardia. Clin Pharmacol Ther 37:186, IV-D, 1985.
Podrid PJ, Lown B: Ethmozin therapy for malignant ventricular arrhythmia. ACC, 1982.
Mann DE, et al: Electrophysiologic effects of ethmozin in patients with ventricular tachycardia. Am Heart J 107:674, 1984.
Chazov EI, et al: Ethmozin II. Effects of intravenous drug administration on atrioventricular nodal reentrant tachycardia. Am Heart J 108:483, 1984.
Morganroth J: Efficacy of moricizine (ethmozine) in the geriatric versus nongeriatric population for the treatment of ventricular arrhythmias. An abstract presented in the international symposium of the cardiovascular system in the elderly—normal aging and clinical problems, Montreux, Switzerland, 30 March-2 April 1987.
Flammang D, Waynberger M: Comparative study of moracizine HC1 (ethmozine®) and amiodarone (cordarone®) in chronic ventricular arrhythmias. An abstract presented in the international symposium of the cardiovascular system in the elderly—normal aging and clinical problems, Montreux, Switzerland, 30 March-2 April 1987.
Gomzyakova TG: Results of clinical study of the antiarrhythmic drug carbazine (ethmozin). Vrach Delo 4:62, 1970.
Golochevskaya VA, Bokeriya OA: Application of ethmozin in patients with heart rhythm disturbances. In: Sivkov II (ed) Questions of pharmacotherapy of some cardiovascular disease. Kukes VG, Moscow, 1971, p 5.
Lozinskiy LG: Experience in the application of the Soviet antiarrhythmic drug ethmozin. Ekspress informatsia VNIIMI “Novyye lekarstvennyye preparate” 10:2, 1975.
Pratt CM: Excellent tolerance of moricizine (ethmozine) in the elderly: special reference to effect on ventricular function. An abstract presented in the international symposium on the cardiovascular system in the elderly—normal aging and clinical problems, Montreux, Switzerland, 20 March-2 April 1987.
Podrid PJ, Mahler SA: Ethmozine toxicity in patients over 65: comparison with a younger population. An abstract presented in the international symposium on the cardiovascular system in the elderly—normal aging and clinical problems, Montreux, Switzerland, 30 March-2 April 2 1987.
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© 1988 Martinus Nijhoff Publishing, Boston
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Schneeweiss, A., Schettler, G. (1988). Ethmozine. In: Cardiovascular Drug Therapy in the Elderly. Developments in Cardiovascular Medicine, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2063-0_31
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DOI: https://doi.org/10.1007/978-1-4613-2063-0_31
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9225-8
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