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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 72))

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Abstract

The bipyridine derivatives, amrinone and milrinone, are agents with positive inotropic and peripheral vasodilatory properties. They are the only orally effective positive inotropic agents except for digitalis glycosides. Therefore, they may be expected to play an important role in treatment of elderly patients with congestive heart failure and sinus rhythm in whom digitalis is often ineffective or not tolerated at therapeutic doses.

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References

Amrinone

  1. Evans DB, et al: In vitro and in vivo cardio-stimulant actions of amrinone and prenalterol [abstr]. Pharmacologist 22:287, 1980.

    Google Scholar 

  2. Alousi AA, et al: Cardiotonic activity of amrinone: Win 40680 (5-amino-3,4′-bipyridin-6(1H)-one). Circ Res 45:666, 1979.

    PubMed  CAS  Google Scholar 

  3. Alousi A, et al: Comparative inotropic activity of amrinone in isolated human atria and cat atria and papillary muscle [abstr]. J Mol Cell Cardiol [Suppl 1] 11:2, 1979.

    Article  Google Scholar 

  4. Benotti JR, et al: Effects of amrinone on myocardial energy metabolism and hemodynamics in patients with severe congestive heart failure due to coronary artery disease. Circulation 62:28, 1980.

    PubMed  CAS  Google Scholar 

  5. Wynne J, et al: Oral amrinone in refractory congestive heart failure. Am J Cardiol 45:1245, 1980.

    Article  PubMed  CAS  Google Scholar 

  6. LeJemtel TH, et al: Sustained beneficial effects of oral amrinone on cardiac and renal function in patients with severe congestive heart failure. Am J Cardiol 45:123, 1980.

    Article  PubMed  CAS  Google Scholar 

  7. LeJemtel TH, et al: Amrinone: a new non-glycosidic, non-adrenergic cardiotonic agent effective in the treatment of intractable myocardial failure in man. Circulation 59:1979.

    Google Scholar 

  8. Packer M, et al: Failure of low doses of amrinone to produce sustained hemodynamic improvement in patients with severe chronic congestive heart failure. Am J Cardiol 54:1025, 1984.

    Article  PubMed  CAS  Google Scholar 

  9. Dibianco R, et al: Oral amrinone for the treatment of chronic congestive heart failure: results of a multicenter randomized double-blind and placebo-controlled withdrawal study. J Am Coll Cardiol 4:855, 1984.

    Article  PubMed  CAS  Google Scholar 

  10. Gaide MS, et al: Characterization of the inotropic and biochemical properties of amrinone: a novel cardiotonic agent [abstr]. Am J Cardiol 45:412, 1980.

    Article  Google Scholar 

  11. Kullberg MP, et al: Amrinone metabolism. Clin Pharmacol Ther 29:394, 1981.

    Article  PubMed  CAS  Google Scholar 

  12. Edelson J, et al: Dose proportionality of amrinone. Clin Pharmacol Ther 34:190, 1983.

    Article  PubMed  CAS  Google Scholar 

  13. Alousi AA, Dobreck HP: Amrinone. In: Scriabine A (ed) New drugs annual: cardiovascular drugs. Raven, New York, 1983.

    Google Scholar 

  14. Wilsmhurst PT, Webb-Peploe MM: Side effects of amrinone therapy. Br Heart J 49:447, 1983.

    Article  PubMed  CAS  Google Scholar 

Milrinone

  1. Bairn DS, et al: Evaluation of a new bipyridine inotropic agent—milrinone—in patients with severe congestive heart failure. N Engl J Med 309:748, 1983.

    Article  Google Scholar 

  2. Maskin CS, et al: Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47209, in patients with severe congestive heart failure. Circulation 67:1065, 1983.

    Article  PubMed  CAS  Google Scholar 

  3. Benotti JR, et al: Pharmacokinetics and pharmacodynamics of milrinone in chronic congestive heart failure. Am J Cardiol 56:685, 1985.

    Article  PubMed  CAS  Google Scholar 

  4. Holmes JR, et al: Milrinone in congestive heart failure: observations on ambulatory ventricular arrhythmias. Am Heart J 110:800, 1985.

    Article  PubMed  CAS  Google Scholar 

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© 1988 Martinus Nijhoff Publishing, Boston

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Schneeweiss, A., Schettler, G. (1988). Bipyridine Derivatives. In: Cardiovascular Drug Therapy in the Elderly. Developments in Cardiovascular Medicine, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2063-0_3

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  • DOI: https://doi.org/10.1007/978-1-4613-2063-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9225-8

  • Online ISBN: 978-1-4613-2063-0

  • eBook Packages: Springer Book Archive

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