Abstract
Minoxidil is a potent arteriolar dilator that increases cardiac output in patients with congestive heart failure (when the patient suffers mainly from low cardiac output) and systemic hypertension. Its mechanism of action is not known. It is effective in the presence of tolerance to conventional vasodilators. Serious adverse effects significantly limit its use.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Nathan M, et al: Effects of acute and chronic minoxidil administration on rest and exercise hemodynamics and clinical status in patients with severe, chronic heart failure. Am J Cardiol 50:960, 1982.
Franciosa JA, Cohn JAN: Effects of minoxidil on hemodynamics in patients with congestive heart failure. Circulation 63:652, 1981.
Packer M, et al: Sustained effectiveness of minoxidil in heart failure after development of tolerance to other vasodilator drugs. Am J Cardiol 48:375, 1981.
McKay CR, et al: Minoxidil therapy in chronic congestive heart failure: acute plus long-term hemodynamic and clinical study. Am Heart J 104:575, 1982.
Markham RV Jr, et al: Central and regional hemodynamic effects and neurohumoral consequences of minoxidil in severe congestive heart failure and comparison to hydralazine and nitroprusside. Am J Cardiol 52:774, 1983.
Franciosa JA, et al: Hemodynamic effects of vasodilators and long-term response in heart failure. J Am Coll Cardiol 3:1521, 1984.
Mehta P, et al: Severe hypertensives: treatment with minoxidil. JAMA 233:249, 1975.
Dargie HJ, et al: Minoxidil in resistant hypertension. Lancet 2:515, 1977.
Gottlieb TB, et al: Pharmacokinetic studies of minoxidil. Clin Pharmacol Ther 13:436, 1972.
Satinsky JD: Chronic heart failure in the elderly: vasodilator therapy. Angiology 35:509, 1982.
Martin WB, et al: Pericardial disorders occurring during open label study of 1,869 severely hypertensive patients treated with minoxidil. J Cardiol Pharmacol [Suppl 2] 2:S217, 1980.
Sobota JT, et al: Minoxidil: right atrial cardiac pathology in animals and in man. Circulation 62:376, 1980.
Campese VM, et al: Treatment of severe hypertension with minoxidil: advantages and limitations. J Clin Pharmacol 19:231, 1979.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1988 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Schneeweiss, A., Schettler, G. (1988). Minoxidil. In: Cardiovascular Drug Therapy in the Elderly. Developments in Cardiovascular Medicine, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2063-0_22
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2063-0_22
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9225-8
Online ISBN: 978-1-4613-2063-0
eBook Packages: Springer Book Archive