Abstract
Prazosin, a balanced vasodilator acting by blockade of postsynaptic alpha-1 adrenoreceptors, is used mainly for treatment of hypertension and congestive heart failure. Several investigators claimed that prazosin is effective also in coronary spasm. Long-term use of prazosin is associated with development of tolerance in a considerable portion of the patients.
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References
Ogasawara B, et al: Plasma renin activity and plasma concentrations of norepinephrine and cyclic nucleotides in heart failure after prazosin. Clin Pharmacol Ther 29:464, 1981.
Goldman SA, et al: Improved exercise ejection fraction with long-term prazosin therapy in patients with heart failure. Am J Med 68:36, 1980.
Packer M, et al: Hemodynamic and clinical tachyphylaxis to prazosin-mediated afterload reduction in severe chronic congestive heart failure. Circulation 59:531, 1979.
Awan NA, et al: Ambulatory prazosin treatment of chronic congestive heart failure: development of late tolerance reversible by higher dosage and interrupted substitution therapy. Am Heart J 101:541, 1981.
Stein L, et al: Acute and chronic haemodynamic effects of prazosin in left ventricular failure. Br Heart J 45:186, 1981.
Colucci WS, et al: Long-term therapy of heart failure with prazosin: a randomized double blind trial. Am J Cardiol 45:337, 1980.
Stokes GS, et al: Long-term use of prazosin in combination or alone for treating hypertension. Med J Aust [Spec Suppl]:13, 1977.
Lund-Johansen P: Hemodynamic changes at rest and during exercise in longterm prazosin therapy for essential hypertension. Postgrad Med J [Spec] 45:77, 1975.
Gould L, et al: Prazosin therapy in congestive heart failure [letter to the editor]. Am Heart J 104:1392, 1982.
Tzivoni D, et al: Prazosin therapy for refractory variant angina. Am Heart J 105:262, 1983.
Chierchia S, et al: α-Adrenergic receptors and coronary spasm: an elusive link. Circulation 69:8, 1984.
Robertson RM, et al: Alpha-adrenergic blockade in vasotonic angina: lack of efficacy of specific alpha1-receptor blockade with prazosin. J Am Coll Cardiol 2:1146, 1983.
Rygnestad TK, Dale O: Self-poisoning with prazosin. Acta Med Scand 213:157, 1983.
Rubin PC, Blachke TF: Studies on the clinical pharmacology of prazosin. 1. Cardiovascular, catecholamine and endocrine changes following a single dose. Br J Clin Pharmacol 10:23, 1980.
Taylor LA, et al: The metabolic fate of prazosin. Xenobiotica 7:357, 1973.
Althius TH, Hess HJ: Synthesis and identification of the major metabolites of prazosin formed in dog and rat. J Med Chem 20:146, 1977.
Rubin PC, et al: Prazosin disposition in young and elderly subjects. Br J Clin Pharmacol 12:401, 1981.
New Zeland Hypertension Study Group: Four to seven year follow up of patients on prazosin. NZ Med J 92:341, 1980.
Seideman P, et al: Prazosin first dose phenomenon during combined treatment with a beta-adrenoceptor blocker in hypertensive patients. Br J Clin Pharmacol 13:865, 1982.
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© 1987 Martinus Nijhoff Publishing, Boston
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Schneeweiss, A., Schettler, G. (1987). Prazosin. In: Cardiovascular Drug Therapy in the Elderly. Developments in Cardiovascular Medicine, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2063-0_16
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DOI: https://doi.org/10.1007/978-1-4613-2063-0_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9225-8
Online ISBN: 978-1-4613-2063-0
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