Abstract
Enalapril is a new angiotensin-converting enzyme inhibitor. Like Captopril, it is a potent dilator of arterial and venous vascular beds, being effective in treatment of congestive heart failure and systemic hypertension. It was suggested that some of the specific serious adverse effects of Captopril may not be produced by enalapril or may have a lower incidence. Enalapril is a pro-drug. It is converted to the biologically active diacid enalaprilat (MK-422) in the liver.
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References
Hockings N, et al: Effects of age on the pharmacodynamic responses to the angiotensin converting enzyme inhibitors enalapril and enalaprilat. In: Proceedings of the BPS, 11–14 September, 1984.
Levine TB, et al: Hemodynamic and clinical response to enalapril, a long-acting converting enzyme inhibitor, in patients with congestive heart failure. Circulation 69:548, 1984.
Wenting GJ, et al: Effects of Captopril in acute and chronic heart failure. Br Heart J 49:65, 1983.
Fitzpatrick D, et al: Haemodynamic, hormonal, and electrolyte effects of enalapril in heart failure. Br Heart J 50:163, 1983.
Di Carlo L, et al: Enalapril: a new angiotensin-converting enzyme inhibitor in chronic heart failure: acute and chronic hemodynamic evaluations. J Am Coll Cardiol 2:865, 1983.
Sharpe DN, et al: Enalapril in patients with chronic heart failure: a placebo-controlled, randomized, double-blind study. Circulation 70:271, 1984.
Moncloa F, et al: Enalapril in hypertension and congestive heart failure: overall review of efficacy and safety. Drugs [Suppl 1] 30:82, 1985.
McCarthy ST, et al: An A.C.E. inhibitor (enalapril) as treatment for resistant cardiac failure. Eur Heart J [Suppl 1] 6:123, 1985.
Messerli FH, Ventura HO: Cardiovascular pathophysiology of essential hypertension: a clue to therapy. Drugs [Suppl 1] 30:25, 1985.
Dunn FG, et al: Enalapril improves systemic and renal hemodynamics and allows regression of left ventricular mass in essential hypertension. Am J Med 53:105, 1984.
Reams GP, Bauer JH: Enalapril versus triple-drug therapy in the treatment of renovascular hypertension. Drugs [Suppl 1] 30:59, 1985.
Cooper W: Effects of enalapril with advancing age. An abstract present in the International Symposium of the Cardiovascular System in the Elderly-Normal Aging and Clinical Problems in the Elderly, 30 March-2 April, 1987, Montreux, Switzerland.
Chrysant SG, et al: Antihypertensive and metabolic effects of a new converting enzyme inhibitor, enalapril. Clin Pharmacol Ther 33:741, 1983.
Ferguson RK, et al: Effects of enalapril, a new converting enzyme inhibitor in hypertension. Clin Pharmacol Ther 32:48, 1982.
Wilkins LH, et al: Enalapril in low-renin essential hypertension. Clin Pharmacol Ther 34:297, 1983.
Schnaper H, et al: Comparison of enalapril and a thiazide diuretic in the elderly. An abstract presented in the International Symposium on the Cardiovascular System in the Elderly — Normal Aging and Clinical Problems, 30 March-2 April, 1987, Montreux, Switzerland.
Biollaz J, Schelling JL, Jacot des Combes B, Brunner DB, Desponds G, Brunner HR, Ulm EH, Hichens M, Gomez HJ: Enalapril maleate and a lysine analogue (MK-521) in normal volunteers; relationship between serum drug levels and the renin angiotensin system. Br J Clin Pharmacol 14:363, 1982.
Brunner DB, Desponds G, Biollaz J, Keller I, Ferber F, Gavras H, Brunner HR, Schelling JL: Effect of a new angiotensin converting enzyme inhibitor MK-421 and its lysine analogue on the components of the renin system in healthy subjects. Br J Clin Pharmacol 11:461, 1981.
Tocco DJ, deLuna FA, Duncan AEW, Vassil TC, Ulm EH: The physiological disposition and metabolism of enalapril maleate (MK-421) in laboratory animals. Drug Metab Dispos 10:15, 1982.
Tempero KP, et al: The safety profile of enalapril. Manufacturers files.
Bender W, et al: Mechanism of deterioration in renal function in patients with renovascular hypertension treated with enalapril. Hypertension [Suppl] 6:I193, 1984.
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© 1988 Martinus Nijhoff Publishing, Boston
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Schneeweiss, A., Schettler, G. (1988). Enalapril. In: Cardiovascular Drug Therapy in the Elderly. Developments in Cardiovascular Medicine, vol 72. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2063-0_10
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DOI: https://doi.org/10.1007/978-1-4613-2063-0_10
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