Chemotherapy for malignant intracranial tumors

  • Paul L. Kornblith
  • Michael Walker
Part of the Cancer Treatment and Research book series (CTAR, volume 36)


Advances in neurosurgical techniques have had a dramatic impact on the prognosis of patients suffering from benign intracranial neoplasms. Acoustic Schwannomas which carried a high surgical mortality rate in Cushing’s era are now removed safely and successfully as are pituitary tumors and most meningiomas. The impact of these technical advances on the management of the malignant intracranial tumors, in particular on the glioblastoma multiforme, the most common primary malignant intracranial neoplasm, have been slight. The use of radiotherapy clearly adds to patient survival but is limited in its effectiveness. Thus, there has been a search for adjunctive approaches to the therapy of malignant gliomas which could hopefully begin to improve the management of these patients. The effective use of chemotherapy has been severely limited by the lack of therapeutic agents designed for use in brain tumor patients and by the heterogeneity of the tumor cells and the drug delivery problems which often prevent the agents from reaching the tumor site. Thus, results of chemotherapy to date have been modest at best.


Brain Tumor Malignant Glioma Malignant Brain Tumor Brain Tumor Patient Cerebellar Astrocytoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishers, Boston 1987

Authors and Affiliations

  • Paul L. Kornblith
  • Michael Walker

There are no affiliations available

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