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Acivicin: A new antimetabolite

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Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 36))

Abstract

Acivicin is an L-glutamine antagonist which underwent phase II clinical efficacy evaluation as an anticancer drug in 1985–1986. The biochemical pharmacology of this agent is unique among antimetabolites and offers several interesting possibilities for combination therapy with agents whose activity can be potentiated by acivicin, with agents which can interfere with cellular resistance to acivicin, and with agents which can lessen the dose-limiting toxicity of acivicin. This review will cover some of the experimental background of current clinical research involving acivicin, will relate clinical findings to the preclinical pharmacology of the drug, and will suggest some new directions for both clinical and preclinical research.

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  1. Robert H. Earhart
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Editors and Affiliations

  1. University of Southern California Cancer Centre, 1441 Eastlake Avenue, 90033, Los Angeles, California, USA

    F. M. Muggia

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Earhart, R.H. (1987). Acivicin: A new antimetabolite. In: Muggia, F.M. (eds) Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy. Cancer Treatment and Research, vol 36. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2061-6_7

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  • DOI: https://doi.org/10.1007/978-1-4613-2061-6_7

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