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Intraperitoneal chemotherapy: Principles and results of clinical trials

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Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 36))

Abstract

While the intraperitoneal administration of chemotherapeutic agents for their cytotoxic rather than sclerosing properties is not a new idea [1,2], recent modelling studies, suggesting a pharmacokinetic rationale for this method of drug delivery to tumors principally confined to the peritoneal cavity, has renewed interest in this idea [3]. In this review the basic principles of intraperitoneal chemotherapy will be presented along with a discussion of the theoretical and practical problems associated with the technique. Finally, a summary of recent single agent and combination intraperitoneal chemotherapy trials will be presented as well as a brief discussion of other innovative approaches utilizing the intraperitoneal route.

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Authors
  1. Maurie Markman
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  2. Stephen B. Howell
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Editors and Affiliations

  1. University of Southern California Cancer Centre, 1441 Eastlake Avenue, 90033, Los Angeles, California, USA

    F. M. Muggia

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Markman, M., Howell, S.B. (1987). Intraperitoneal chemotherapy: Principles and results of clinical trials. In: Muggia, F.M. (eds) Concepts, Clinical Developments, and Therapeutic Advances in Cancer Chemotherapy. Cancer Treatment and Research, vol 36. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2061-6_2

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  • DOI: https://doi.org/10.1007/978-1-4613-2061-6_2

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