The Role of the Lipid Bilayer in Amphiphile-Membrane/Receptor Interactions: A Unifying Hypothesis

Herbette, L. G.; Gruner, S. M.

doi:10.1007/978-1-4613-2057-9_28

The Role of the Lipid Bilayer in Amphiphile-Membrane/Receptor Interactions: A Unifying Hypothesis

L. G. Herbette² &
S. M. Gruner³

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 68))

Abstract

The precise nature of the interaction of amphiphilic¹ substances, such as drugs, with native biological membranes is complex for a variety of reasons, not the least of which is the number of potential membrane sites. Certainly, small molecular substances with different chemical constituents may interact preferentially with one or more different regions of a biomembrane. These regions include but are not limited to (1) the bulk lipid matrix; (2) the lipid annular region of an integral membrane protein; (3) the hydrophobic and (4) the hydrophilic regions of a membrane protein; and (5) the glycosylated moieties attached to both lipid and protein components.

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Authors and Affiliations

Department of Radiology, Medicine and Biochemistry, University of Connecticut Health Center, 06032, Farmington, CT, USA
L. G. Herbette
Department of Physics, Princeton University, 08544, Princeton, NJ, USA
S. M. Gruner

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L. G. Herbette
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S. M. Gruner
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Editors and Affiliations

Youville Research Institute, St. Boniface General Hospital and Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Robert E. Beamish , Vincenzo Panagia & Naranjan S. Dhalla , &

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Herbette, L.G., Gruner, S.M. (1987). The Role of the Lipid Bilayer in Amphiphile-Membrane/Receptor Interactions: A Unifying Hypothesis. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pharmacological Aspects of Heart Disease. Developments in Cardiovascular Medicine, vol 68. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2057-9_28

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DOI: https://doi.org/10.1007/978-1-4613-2057-9_28
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9222-7
Online ISBN: 978-1-4613-2057-9
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