New Approaches for the Treatment of the Failing Myocardium: Myofibrillar Proteins as Potential Targets for Pharmacotherapy

  • Edward D. Pagani
  • Adawia A. Alousi
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 68)


A new approach for the development of pharmacological agents to treat myocardial cell failure that is fundamentally different from the more traditional approaches used in the development of positive inotropic agents is beginning to emerge. The traditional approaches, in general, rely heavily on screening chemical compounds in a biological system with the aim of identifying compounds that have inotropic activity. The new approach is different in that a specific enzyme or cellular process that is identified to be defective in failing heart muscle is targeted for chemical modification with the goal of improving diastolic and/or systolic performance of the heart and raising cardiac output. Associated with the new approach is the possibility that by reversing the defect in failing heart muscle cells the progression of the disease may be slowed or even prevented. Although in both the new approach and traditional approach the final objective in treating myocardial cell failure may be the same, the pathways leading to the objective are very different, as could be the potential long range result.


ATPase Activity Actin Filament Cardiac Muscle Sarcomere Length Myofibrillar Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • Edward D. Pagani
    • 1
  • Adawia A. Alousi
    • 1
  1. 1.Molecular Cardiology UnitSterling-Winthrop Research InstituteRensselaerUSA

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