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Classification and Mechanism of Action of the Cardiac Inotropic Agents: An Overview

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Pharmacological Aspects of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 68))

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Abstract

The cardiac inotropic agents are substances that modify cardiac muscle contraction by acting directly on the myocardium (1). These agents could be categorized into two major classes; positive inotropic agents that stimulate cardiac muscle contraction such as the cardiac glycosides (2), the catecholamines (3) and the bipyridines (4), and negative inotropic agents that depress cardiac contraction such as the β-adrenergic blockers, the antiarrhythmics and the barbiturates (5).

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References

  1. Alousi, A.A. and Farah, A.E., Trend Pharmacol. Sci. 1: 143–146, 1980.

    Article  CAS  Google Scholar 

  2. Grupp, G., Grupp, I.L., Hickerson, T., Lee, S.W. and Schwartz, A. In: Cardiac Glycosides 1785-1985. (Eds. E. Erdmann, K. Greef and J.C. Skou), Stinkopff Verlag Darmstadt, Springer-Verlag, New York, 1986, pp. 99–108.

    Google Scholar 

  3. Scholtz, H. In: Handbook of Experimental Pharmacology, Adrenergic Activators and Inhibitors, (Ed. L. Szekeres), Springer-Verlag, Berlin/ Heidelberg/New York, 54(1): 651–733, 1980.

    Google Scholar 

  4. Alousi, A.A., Fabian, R.J., Baker, J.F. and Stroshane, R.M. In: New Drugs Annual: Cardiovascular Drugs (Ed. A. Scriabine), Raven Press, New York, 3:245–283, 1985.

    Google Scholar 

  5. Alousi, A.A., Canter, J.M. and Fort, D.J. Cardiovas. Res. 19: 483–494, 1985.

    Article  CAS  Google Scholar 

  6. Braunwald, E. In: Heart Disease (Ed. E. Braunwald), W.B. Saunders Comp., Philadelphia, London, Toronto, 1984, pp. 453–471.

    Google Scholar 

  7. Colucci, W.S., Wright, R.F. and Braunwald, E. New. Engl. J. Med. 314: 349–358, 1986.

    Article  PubMed  CAS  Google Scholar 

  8. Goldberg, L.I. Pharmacol. Rev. 24: 1–29, 1972.

    PubMed  CAS  Google Scholar 

  9. Tuttle, R.R., Mills, J. Circ. Res. 36: 185–196, 1975.

    PubMed  CAS  Google Scholar 

  10. Katz, A. In: Physiology of the Heart (Ed. A. Katz), Raven Press, 1977, pp. 107–119.

    Google Scholar 

  11. Stull, J.T. and Mayer, S.E. In: Handbook of Physiology, The Cardiovascular System, Vol. I. The Heart. (Eds. R.M. Berne, N. Sperelakis and S.R. Geiger). The Physiological Soc., Bethesda, Maryland, 1979, pp. 741–774.

    Google Scholar 

  12. Ruegg, J.C. Cir. Res. Supp. 73: III, 78–84, 1986.

    Google Scholar 

  13. Hoh, J.F.Y., McGrath, P.A. and Hale, P.T. J. Mol. Cell. Cardiol. 10: 1053–1076, 1978.

    Article  PubMed  CAS  Google Scholar 

  14. Pagani, E.D. and Julian, F.J. Circ. Res. 54: 586–594, 1984.

    PubMed  CAS  Google Scholar 

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© 1987 Martinus Nijhoff Publishing, Boston

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Alousi, A.A. (1987). Classification and Mechanism of Action of the Cardiac Inotropic Agents: An Overview. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pharmacological Aspects of Heart Disease. Developments in Cardiovascular Medicine, vol 68. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2057-9_26

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  • DOI: https://doi.org/10.1007/978-1-4613-2057-9_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9222-7

  • Online ISBN: 978-1-4613-2057-9

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