Influences of a Long-Term Treatment with Antihypertensive Drugs on Left Ventricular Myosin Isoenzyme Pattern in Spontaneously Hypertensive Rats

  • N. Takeda
  • M. Kanemura
  • K. Noma
  • T. Ohkubo
  • M. Nagano
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 68)


Rat’s left ventricular myosin is separated into three isoenzymes by pyrophosphate gel electrophoresis (1–3),i.e. VM-1,2,3, which have greater electrophoretic mobility and ATPase activity in order. Thyroid hormone’s administration and endurance swimming training can induce the shift of ventricular myosin isoenzyme pattern towards VM-1. Aging, chronic pressure overload and thyreostatic treatment, on the other hand, can shift the pattern towards VM-3 (4–12). The shift of myosin isoenzyme pattern towards VM-3 in pressure overloaded myocardium is thought to be an adaptational process to keep force development efficient with low oxygen and energy utilization (13,14). In spontaneously hypertensive rats (SHR) the concentration of VM-3 isomyosin in left ventricle is higher than that of age-matched normotensive rats. The aim of the present study is to examine to what extent alters myosin isoenzyme pattern with some antihypertensive drugs.


Antihypertensive Drug Heart Weight Body Weight Ratio Adrenergic System Group Blood Pressure 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • N. Takeda
    • 1
  • M. Kanemura
    • 1
  • K. Noma
    • 1
  • T. Ohkubo
    • 1
  • M. Nagano
    • 1
  1. 1.Department of Internal MedicineAoto Hospital, Jikei UniversityTokyoJapan

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