Influences of a Long-Term Treatment with Antihypertensive Drugs on Left Ventricular Myosin Isoenzyme Pattern in Spontaneously Hypertensive Rats

  • N. Takeda
  • M. Kanemura
  • K. Noma
  • T. Ohkubo
  • M. Nagano
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 68)

Abstract

Rat’s left ventricular myosin is separated into three isoenzymes by pyrophosphate gel electrophoresis (1–3),i.e. VM-1,2,3, which have greater electrophoretic mobility and ATPase activity in order. Thyroid hormone’s administration and endurance swimming training can induce the shift of ventricular myosin isoenzyme pattern towards VM-1. Aging, chronic pressure overload and thyreostatic treatment, on the other hand, can shift the pattern towards VM-3 (4–12). The shift of myosin isoenzyme pattern towards VM-3 in pressure overloaded myocardium is thought to be an adaptational process to keep force development efficient with low oxygen and energy utilization (13,14). In spontaneously hypertensive rats (SHR) the concentration of VM-3 isomyosin in left ventricle is higher than that of age-matched normotensive rats. The aim of the present study is to examine to what extent alters myosin isoenzyme pattern with some antihypertensive drugs.

Keywords

Glycerol Amide Electrophoresis Cardiol Verapamil 

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References

  1. 1.
    Hoh, J.F.Y., McGrath, P.A. and Hale, P.T. J.Mol.Cell. Cardiol. 10: 1053–1076,1978.PubMedCrossRefGoogle Scholar
  2. 2.
    d’Albis, A., Pantaloni, C. and Becher, J.-J. Eur.J.Biochem. 99: 261–272,1979.PubMedCrossRefGoogle Scholar
  3. 3.
    Rupp, H. and Jacob, R. Can.J.Physiol.Pharmacol. 60: 1098–1103,1982.PubMedCrossRefGoogle Scholar
  4. 4.
    Lompre, A.-M., Schwartz, K., d’Albis, A., Lacombe, G., Van Thiem, N. and Swyghedauw, B. Nature 282:105–107.1979.PubMedCrossRefGoogle Scholar
  5. 5.
    Mercadier, J.J., Lompre, A.M., Wisnewsky, C., Samuel, J.L., Bercovici, J., Swynghedauw, B. and Schwartz, K. Circ.Res. 49: 525–532,1981.PubMedGoogle Scholar
  6. 6.
    Rupp, H. Basic.Res.Cardiol. 76: 79–88,1981.PubMedCrossRefGoogle Scholar
  7. 7.
    Alpert, N.R., Mulieri, L.A. and Litten, R.Z. In: Cardiac adaptation to hemodynanic overload, training and stress (Eds. R. Jacob, R.W. Gülch and Kissling), Dr. D. Steinkopff Verlag, Darmstadt, 1982, pp.147-157.Google Scholar
  8. 8.
    Jacob, R., Rupp, H., Ebrecht, G., Holubarsch, Ch. and Kissling, G. Z.Kardiol. 71: 553–565,1982.PubMedGoogle Scholar
  9. 9.
    Martin, A.F., Pagani, E.D. and Solaro, R.J. Circ.Res. 50: 117–124,1982.PubMedGoogle Scholar
  10. 10.
    Rupp, H. Basic.Res.Cardiol. 77: 34–46,1982.PubMedCrossRefGoogle Scholar
  11. 11.
    Takeda, N., Dominiak, P., Turck, D., Rupp, H. and Jacob, R. Basic.Res.Cardiol. 80: 88–99,1985.PubMedCrossRefGoogle Scholar
  12. 12.
    Takeda, N., Dominiak, P., Turck, D., Rupp, H. and Jacob, R. Basic.Res.Cardiol. 80: 384–391,1985.PubMedCrossRefGoogle Scholar
  13. 13.
    Jacob, R., Rupp, H., Ebrecht, G., Gulch, R.W. and Kissling, G. In: Cardiac structure and metabolism 4 (Eds. M. Nagano and I. Seki), Roppo Shuppansha, Tokyo, 1981,pp. 1–28.Google Scholar
  14. 14.
    Jacob, R., Kissling, G., Ebrecht,G., Holubarsch,Ch., Medugorac,I. and Rupp,H. In: Advances in Myocardiology 4 (Eds. E. Chazov, V. Saks and G. Rona), Plenum Publishing Corporation, New York, 1983, pp.55–77.Google Scholar
  15. 15.
    Sen, S., Tarazi, R.C, Khairallah, P.A. and Bumpus, F.M. Circ.Res. 35: 775–781,1974.PubMedGoogle Scholar
  16. 16.
    Sen, S., Tarazi, R.C. and Bumpus, F.M. Cardiovasc.Res. 11: 427–433,1977.PubMedCrossRefGoogle Scholar
  17. 17.
    Pegram, B.L., Ishise, S. and Frohlich, E.D. Cardiovasc. Res. 16: 40–46,1982.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • N. Takeda
    • 1
  • M. Kanemura
    • 1
  • K. Noma
    • 1
  • T. Ohkubo
    • 1
  • M. Nagano
    • 1
  1. 1.Department of Internal MedicineAoto Hospital, Jikei UniversityTokyoJapan

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