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Molecular Events Occurring During Post-Ischaemic Reperfusion

  • Chapter
Myocardial Ischemia

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 67))

Abstract

The availability of techniques such as surgical reperfusion, angioplasty and thrombolysis for the restoration of blood flow to the ischaemic myocardium has revived interest in the reperfusion phenomenon (1,2,3). It is clear that reperfusion occupies a central role in tissue protection as, without it, no recovery is possible at all (4). Reperfusion, however is not necessarily beneficial and it has been reported that it can accelerate the rate of development of necrosis (4,5,6,7,8). The available data on the use of intracoronary infusion of streptokinase or urokinase for the dissolution of clot have shown recanalization rates of up 90% which are not necessarily accompained by a recovery of myocardial function. Like in animal studies, the recovery of metabolical and functional capacities of the previous ischaemic zone seems to depend on the duration of the ischaemic period (11,12,13). Thus, the biochemical events leading to the irreversibility of the ischaemic myocites and the possibility of improving recovery by acting directly during reperfusion represent a very important clinical problem.

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Authors and Affiliations

  1. Cattedra di Cardiologia e Cattedra di Chimica, Universita’ degli Studi di Brescia, 25100, Brescia, Italy

    R. Ferrari, C. Ceconi, S. Curello, A. Cargnoni, A. Albertini & E. O. Visioli

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  1. R. Ferrari
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  2. C. Ceconi
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  3. S. Curello
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  4. A. Cargnoni
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  5. A. Albertini
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  6. E. O. Visioli
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Editor information

Editors and Affiliations

  1. Youville Research Institute, St. Boniface General Hospital, and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla , Ian R. Innes  & Robert E. Beamish ,  & 

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© 1987 Springer Science+Business Media Dordrecht

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Ferrari, R., Ceconi, C., Curello, S., Cargnoni, A., Albertini, A., Visioli, E.O. (1987). Molecular Events Occurring During Post-Ischaemic Reperfusion. In: Dhalla, N.S., Innes, I.R., Beamish, R.E. (eds) Myocardial Ischemia. Developments in Cardiovascular Medicine, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2055-5_6

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  • DOI: https://doi.org/10.1007/978-1-4613-2055-5_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9221-0

  • Online ISBN: 978-1-4613-2055-5

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