Effect of Nifedipine and Hyaluronidase Alone and in Combination on Myocardial Preservation in Experimental Myocardial Infarction — A Morphological and Biochemical Profile

  • M. P. Gupta
  • S. D. Seth
  • S. C. Manchanda
  • Uma Singh
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 67)


The extent of myocardial necrosis subsequent to coronary artery occlusion is of utmost significance, because the patient’s survival depends largely on the extent of damage and the reversibility of ischemic tissue. Though various pharmacological interventions have been found to have some salutory effects on the ischemic myocardium, nevertheless, no drug administered singly has been shown to be totally effective in preventing further damage or to retrieve the ischemic tissue. Hence the combinations of various cardioprotective drugs, eg; calcium channel blockers, beta-blockers, nitroglycerine etc. are being investigated for their synergistic effects (1–6).


Left Ventricular Mass Coronary Occlusion Creatine Phosphokinase Viable Tissue Triphenyl Tetrazolium Chloride 
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Copyright information

© Springer Science+Business Media Dordrecht 1987

Authors and Affiliations

  • M. P. Gupta
    • 2
  • S. D. Seth
    • 2
  • S. C. Manchanda
    • 1
  • Uma Singh
    • 2
  1. 1.Departments of Pharmacology and CardiologyAll-India Institute of Medical SciencesIndia
  2. 2.All-India Institute of Medical SciencesIndia

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