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Effect of Nifedipine and Hyaluronidase Alone and in Combination on Myocardial Preservation in Experimental Myocardial Infarction — A Morphological and Biochemical Profile

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Myocardial Ischemia

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 67))

Abstract

The extent of myocardial necrosis subsequent to coronary artery occlusion is of utmost significance, because the patient’s survival depends largely on the extent of damage and the reversibility of ischemic tissue. Though various pharmacological interventions have been found to have some salutory effects on the ischemic myocardium, nevertheless, no drug administered singly has been shown to be totally effective in preventing further damage or to retrieve the ischemic tissue. Hence the combinations of various cardioprotective drugs, eg; calcium channel blockers, beta-blockers, nitroglycerine etc. are being investigated for their synergistic effects (1–6).

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Author information

Authors and Affiliations

  1. Departments of Pharmacology and Cardiology, All-India Institute of Medical Sciences, 110 029, New Delhi, India

    S. C. Manchanda

  2. All-India Institute of Medical Sciences, 110 029, New Delhi, India

    M. P. Gupta, S. D. Seth & Uma Singh

Authors
  1. M. P. Gupta
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  2. S. D. Seth
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  3. S. C. Manchanda
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  4. Uma Singh
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Editor information

Editors and Affiliations

  1. Youville Research Institute, St. Boniface General Hospital, and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla , Ian R. Innes  & Robert E. Beamish ,  & 

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Gupta, M.P., Seth, S.D., Manchanda, S.C., Singh, U. (1987). Effect of Nifedipine and Hyaluronidase Alone and in Combination on Myocardial Preservation in Experimental Myocardial Infarction — A Morphological and Biochemical Profile. In: Dhalla, N.S., Innes, I.R., Beamish, R.E. (eds) Myocardial Ischemia. Developments in Cardiovascular Medicine, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2055-5_26

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  • DOI: https://doi.org/10.1007/978-1-4613-2055-5_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9221-0

  • Online ISBN: 978-1-4613-2055-5

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