Skip to main content
SpringerLink
Log in

Phosphorus Nuclear Magnetic Resonance Measurements of Intracellular pH in Isolated Rabbit Heart During the Calcium Paradox

  • Chapter
Myocardial Ischemia

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 67))

  • 70 Accesses

Abstract

In 1883 Ringer [1] reported that contraction of an isolated frog heart rapidly ceased when calcium was removed from the extracellular fluid. Similar experiments with isolated rat hearts were performed by Zimmerman and Hülsmann [2]. During perfusion with a calcium-free solution contraction of the heart ceased while electrical activity was maintained. They reported: “Returning to a normal perfusate after more than 2 min resulted in the disappearance of the electrocardiogram, and, after the heart had contracted a few times, these contractions passed off completely and contractile activity was not restored. The heart lost its colour and acquired a pale and mottled appearance. This phenomenon, whereby the heart maintained its red colour and electrical activity when the perfusion medium was changed from normal to calcium-free, but lost these properties on return to normal, we called the calcium paradox.” The calcium paradox has been demonstrated in rat, mouse, guinea-pig, rabbit and dog heart [3,4], in superfused strips of the human heart [5], and also in the frog heart [6] although the amphibian heart is more resistant to the calcium paradox than the mammalian heart.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ringer, S. J. Physiol. 4: 29–42, 1883.

    PubMed  CAS  Google Scholar 

  2. Zimmerman, A.N.E. and Hülsmann, W.C. Nature 211: 646–647, 1966.

    Article  PubMed  CAS  Google Scholar 

  3. Hearse, D.J., Humphrey, S.M., Boink, A.B.T.J, and Ruigrok, T.J.C. Eur. J. Cardiol. 7: 241–256, 1978.

    PubMed  CAS  Google Scholar 

  4. Zimmerman, A.N.E., Daems, W., Hülsmann, W.C., Snijder, J., Wisse, E. and Durrer, D. Cardiovasc. Res. 1: 201–209, 1967.

    Article  CAS  Google Scholar 

  5. Lomský, M., Ekroth, R. and Poupa, O. Eur. Heart J. 4 (Suppl. H): 139–142, 1983.

    Article  PubMed  Google Scholar 

  6. Ruigrok, T.J.C., Slade, A.M. and Poole-Wilson, P.A. Eur. Heart J. 4 (Suppl. H): 89–96, 1983.

    Article  PubMed  CAS  Google Scholar 

  7. Alto, L.E. and Dhalla, N.S. Am. J. Physiol. 237: H713-H719, 1979.

    PubMed  CAS  Google Scholar 

  8. Nayler, W.G., Elz, J.S., Perry, S.E. and Daly, M.J. Eur. Heart J. 4 (Suppl. H): 29–41, 1983.

    Article  PubMed  CAS  Google Scholar 

  9. Ruigrok, T.J.C. In: Control and Manipulation of Calcium Movement (Ed. J.R. Parratt), Raven Press, New York, 1985, pp. 341–365.

    Google Scholar 

  10. Meno, H., Kanaide, H. and Nakamura, M. J. Pharmacol. Exp. Ther. 228: 220–224, 1984.

    CAS  Google Scholar 

  11. Ohhara, H., Kanaide, H. and Nakamura, M. J. Mol. Cell. Cardiol. 14: 13–20, 1982.

    Article  PubMed  CAS  Google Scholar 

  12. Dhalla, N.S., Alto, L.E. and Singal, P.K. Eur. Heart J. 4 (Suppl. H): 51–56, 1983.

    Article  PubMed  CAS  Google Scholar 

  13. Nayler, W.G., Perry, S.E., Elz, J.S. and Daly, M.J. CIrc. Res. 55: 227–237, 1984.

    Article  PubMed  CAS  Google Scholar 

  14. Lamers, J.M.J., Stinis, J.T. and Ruigrok, T.J.C. Circ. Res. 54: 217–226, 1984.

    Article  PubMed  CAS  Google Scholar 

  15. Lamers, J.M.J, and Ruigrok, T.J.C. Eur. Heart J. 4 (Suppl. H): 73–79, 1983.

    Article  PubMed  CAS  Google Scholar 

  16. Preuner, J. Basic Res. Cardiol. 80 (Suppl. 2), 19–24, 1985.

    PubMed  CAS  Google Scholar 

  17. Ruigrok, T.J.C., Boink, A.B.T.J., Spies, F., Blok, F.J., Maas, A.H.J, and Zimmerman, A.N.E. J. Mol. Cell. Cardiol. 10: 991–1002, 1978.

    Article  PubMed  CAS  Google Scholar 

  18. Grinwald, P.M. and Nayler, W.G. J. Mol. Cell. Cardiol. 13: 867–880, 1981.

    Article  PubMed  CAS  Google Scholar 

  19. Ganote, C.E. and Nayler, W.G. J. Mol. Cell. Cardiol. 17: 733–745, 1985.

    Article  CAS  Google Scholar 

  20. Post, J.A., Nievelstein, P.F.E.M., Leunissen-Bijvelt, J., Verkleij, A.J. and Ruigrok, T.J.C. J. Mol. Cell. Cardiol. 17: 265–273, 1985.

    Article  PubMed  CAS  Google Scholar 

  21. Brierley, G.P., Murer, E. and Bachmann, E. Arch. Biochem. Biophys. 105: 89–102, 1964.

    Article  PubMed  CAS  Google Scholar 

  22. Gevers, W. J. Mol. Cell. Cardiol. 9: 867–874, 1977.

    Article  PubMed  CAS  Google Scholar 

  23. Langendorff, O. Pfluegers Arch. 61: 291–332, 1895.

    Article  Google Scholar 

  24. Boink, A.B.T.J., Ruigrok, T.J.C., Maas, A.H.J, and Zimmerman, A.N.E. J. Mol. Cell. Cardiol. 8: 973–979, 1976.

    Article  CAS  Google Scholar 

  25. Ruigrok, T.J.C., Boink, A.B.T.J., Slade, A., Zimmerman, A.N.E., Meijler, F.L. and Nayler, W.G. Am. J. Pathol. 98: 769–790, 1980.

    PubMed  CAS  Google Scholar 

  26. Ruigrok, T.J.C., Van Echteld, C.J.A., De Kruijff, B., Borst, C. and Meijler, F.L. Eur. Heart J. 4 (Suppl. C): 109–113, 1983.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cardiology, University Hospital, Catharijnesingel 101, 3511 GV, Utrecht, The Netherlands

    T. J. C. Ruigrok, C. Borst & F. L. Meijler

  2. Interuniversity Cardiology Institute of The Netherlands, The Netherlands

    T. J. C. Ruigrok, J. H. Kirkels, C. J. A. Van Echteld & F. L. Meijler

Authors
  1. T. J. C. Ruigrok
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. H. Kirkels
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. J. A. Van Echteld
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. Borst
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. L. Meijler
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Youville Research Institute, St. Boniface General Hospital, and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla , Ian R. Innes  & Robert E. Beamish ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Science+Business Media Dordrecht

About this chapter

Cite this chapter

Ruigrok, T.J.C., Kirkels, J.H., Van Echteld, C.J.A., Borst, C., Meijler, F.L. (1987). Phosphorus Nuclear Magnetic Resonance Measurements of Intracellular pH in Isolated Rabbit Heart During the Calcium Paradox. In: Dhalla, N.S., Innes, I.R., Beamish, R.E. (eds) Myocardial Ischemia. Developments in Cardiovascular Medicine, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2055-5_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2055-5_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9221-0

  • Online ISBN: 978-1-4613-2055-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation