Protective and Nonprotective Effects of Drugs on Cardiac Contractile Activity and High Energy Phosphates During Anoxia and After Reoxygenation

  • M. Siess
  • U. Delabar
  • K. Stieler
  • J. Leuchtner
  • I. Teutsch
  • A. Khattab
  • M. B. El Hawary
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 67)


One important field of basic research in cardiology has been focused during the last decade on possible cardioprotective or -nonprotective interventions in energy metabolism or performance to improve the cardiac cell survival during periods of anoxic or hypoxic cardioplegia and during the critical phase of reoxygenation in cardiothoracic surgery (1, 9). With a recently developed ‘anoxia test’ as a model (2, 3, 6) using super-fused left guinea pig atria at rest or at a reduced anoxic contractile work, we have studied
  1. - a)

    influences on high energy phosphate levels and on the energy quotient (ATP/(ADP + AMP)) with precursors of AN (adenine nucleotide)-, NAD and CP-synthes is (adenine, ribose, nicotinicacid,. creatine),

  2. - b)

    influences of drugs on contractile activity, measuring the auxotonic contractile work/beat and work/hr

during normoxia, anoxia and reoxygenation independent from hemodynamic factors. In this chapter we want to give a short review about some essential points of our findings which may be perhaps of general interest.


Nicotinic Acid Left Atrium Contractile Activity Positive Inotropic Effect Cardioplegic Solution 
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Copyright information

© Springer Science+Business Media Dordrecht 1987

Authors and Affiliations

  • M. Siess
    • 1
  • U. Delabar
    • 1
  • K. Stieler
    • 1
  • J. Leuchtner
    • 1
  • I. Teutsch
    • 1
  • A. Khattab
    • 2
  • M. B. El Hawary
    • 2
  1. 1.Department of Pharmacology, Medical FacultyUniversity of TuebingenGermany
  2. 2.Department of Pharmacology, Medical SchoolUniversity of CairoEgypt

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