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Myocardial Ischemia pp 149–161Cite as

Morphometric Analysis of Regional Myocardial Perfusion in Rats as Measured by Non-Radioactive Microspheres

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 67))

Abstract

The radioactive microsphere technique is the most accurate method currently available for measuring regional myocardial perfusion in experimental animals. It is based on the principle that microspheres distributei n proportion to regional myocardial blood flow if the basic criteria of the technique are satisfied (1). However, this assumption is not substantiated since microsphere distribution is determined indirectly from measurements of tissue radioactivity. Furthermore, the use of relatively large tissue samples for accurate measurements decreases spatial resolution and, therefore, prevents studies of regional myocardial perfusion in smaller animals.

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Authors and Affiliations

  1. Department of Physiology, University of Ottawa, K1H 8M5, Ottawa, Canada

    M. Korpan & K. Rakusan

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  1. M. Korpan
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  2. K. Rakusan
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Editors and Affiliations

  1. Youville Research Institute, St. Boniface General Hospital, and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla , Ian R. Innes  & Robert E. Beamish ,  & 

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© 1987 Springer Science+Business Media Dordrecht

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Korpan, M., Rakusan, K. (1987). Morphometric Analysis of Regional Myocardial Perfusion in Rats as Measured by Non-Radioactive Microspheres. In: Dhalla, N.S., Innes, I.R., Beamish, R.E. (eds) Myocardial Ischemia. Developments in Cardiovascular Medicine, vol 67. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2055-5_13

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  • DOI: https://doi.org/10.1007/978-1-4613-2055-5_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9221-0

  • Online ISBN: 978-1-4613-2055-5

  • eBook Packages: Springer Book Archive

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