Abstract
The main systems involved in the regulation of the internal Na+ level in the cardiac cells are presented in Fig. 1. They include (i) the (Na+,K+)ATPase that is the major efflux system for Na+ (1), (ii) the Na+/H+ exchange system that is the major influx system (2, 3), (iii) the Na+/K+/Cl− co-transport, (iv) the Na+/Ca2 exchange system. This latter system works in both directions (Na+ influx coupled to Ca2+ efflux or vice-versa) but only the mode corresponding to Ca2+ influx coupled to Na+ influx will be considered here in relation with inotropy.
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References
Kazazoglou, T., Renaud, J.F., Rossi, B. and Lazdunski, M. J. Biol. Chem. 258: 12163–12170, 1983.
Frelin, C, Vigne, P. and Lazdunski, M. J. Biol. Chem. 259: 8880–8885, 1984.
Lazdunski, M., Frelin, C. and Vigne, P. J. Moll. Cell. Cardiol. 17: 1029–1042, 1985.
Colquhoun, D., Neher, E., Reuter, H. and Stevens, C.F. Nature 294: 752–754, 1981.
Frelin, C, Vigne, P. and Lazdunski, M. Eur. J. Biochem. 149: 1–4, 1985.
Vigne, P., Frelin, C. and Lazdunski, M. J. Biol. Chem. 257: 9394–9400, 1982.
Green, R.D., Frelin, C, Vigne, P. and Lazdunski, M. FEBS Lett. J96: 163–166, 1986.
Piwnica-Worms, D. and Liberman, M. Am. J. Physiol. 244: C422–C428, 1983.
Piwnica-Worms, D., Jacob, R., Horres, C.R. and Liberman, M. J. Gen. Physiol. 85: 43–64, 1985
Vigne, P., Frelin, C, Cragoe, E.J. and Lazdunski, M. Mol Pharmacol. 25: 131–136, 1984.
Vigne, P., Frelin, C, Cragoe, E.J. and Lazdunski, M. Biochem. Biophys. Res. Commun. 116: 86–90, 1983.
Frelin, C, Chassande, O. and Lazdunski, M. Biochem. Biophys. Res. Commun. 134: 326–331, 1986.
Piwnica-Worms, D., Jacob, R., Horres, C.R. and Liberman, M. Am. J. Physiol. 249: C337–344, 1985.
Lazdunski, M. and Renaud, J.F. Ann. Rev. Physiol. 44: 463–473, 1982.
Romey, G., Renaud, J.F., Fosset, M. and Lazdunski, M. J. Pharm. Exp. Ther. 213: 607–615, 1980.
Renaud, J.F., Fosset, M., Schweitz, H. and Lazdunski, M. Eur. J. Pharmacol. 120: 161–170, 1986.
Romey, G., Quast, U., Pauron, D., Frelin, C, Renaud, J.F. and Lazdunski, M. Proc. Natl. Acad. Sci. USA in press, 1987.
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© 1987 Martinus Nijhoff Publishing, Boston
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Lazdunski, M. et al. (1987). Sodium Pathways In and Out of the Cardiac Cells: Relationship to Inotropy. In: Dhalla, N.S., Pierce, G.N., Beamish, R.E. (eds) Heart Function and Metabolism. Developments in Cardiovascular Medicine, vol 66. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2053-1_5
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DOI: https://doi.org/10.1007/978-1-4613-2053-1_5
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