Isomyosins and Isoactins in Mammalian Myocardium

  • J. J. Mercadier
  • A. M. Lompre
  • D. de la Bastie
  • J. L. Samuel
  • B. Swynghedauw
  • L. Rappaport
  • K. Schwartz
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 66)

Abstract

Myosin and actin are the major components of the thick and the thin filaments of the sarcomere, respectively. The existence of several isomyosins with different heavy chains and different enzymatic activities was demonstrated more than 20 years ago when adult fast-twitch and slow-twitch muscles were compared to cardiac ventricular tissue and it is clear now that the sarcomeric myosin heavy chains (MHC) are coded by a highly conserved multigene family (l). The classical experiments of Barany (2) who showed that maximal velocity of a given muscle fiber is correlated to the ATPase activity of its constituent myosin, and of Buller, Eccles and Eccles (3) in which the nerve was shown to modulate the properties of a muscle, opened an exciting new era in muscle research and neurobiology.

Keywords

Cardiol Hypothyroidism Thyroxine 

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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • J. J. Mercadier
    • 1
  • A. M. Lompre
    • 1
  • D. de la Bastie
    • 1
  • J. L. Samuel
    • 1
  • B. Swynghedauw
    • 1
  • L. Rappaport
    • 1
  • K. Schwartz
    • 1
  1. 1.Unité 127 I.N.S.E.R.MHopital LariboisièreParisFrance

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