Abstract
Myosin and actin are the major components of the thick and the thin filaments of the sarcomere, respectively. The existence of several isomyosins with different heavy chains and different enzymatic activities was demonstrated more than 20 years ago when adult fast-twitch and slow-twitch muscles were compared to cardiac ventricular tissue and it is clear now that the sarcomeric myosin heavy chains (MHC) are coded by a highly conserved multigene family (l). The classical experiments of Barany (2) who showed that maximal velocity of a given muscle fiber is correlated to the ATPase activity of its constituent myosin, and of Buller, Eccles and Eccles (3) in which the nerve was shown to modulate the properties of a muscle, opened an exciting new era in muscle research and neurobiology.
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References
Nguyen, H.T., Gubits, R.M., Wydro, R.M. and Nadal-Ginard, B. Proc. Natl. Acad. Sci. USA 79: 5230–5234, 1982.
Barany, M. J. Gen. Physiol. 150: 197–216, 1967.
Buller, A.J., Eccles, J.C. and Eccles, R.M. J. Physiol. 150: 417–439, 1960.
Hoh, J.F.Y., McGrath, P.A. and Hale, P.T. J. Mol. Cell. Cardiol. 10: 1053–1076, 1978.
Schwartz, K. and Mercadier, J.J. In: The Developing Heart (Ed. M. Legato), Martinus Nijhoff Publishing, Boston, The Hague, Dordrecht, Lancaster, 1984, pp. 149–171.
Schwartz, K., Lecarpentier, Y., Martin, J.L., Lompré, A.M., Mercadier, J.J. and Swynghedauw, B. J. Moll. Cell. Cardiol. 13: 1071–1075, 1981.
Alpert, N.R. and Mulieri, L.A. Circ. Res. 50: 491–500, 1982.
Goldman, S., Olajos, M. and Morkin, E. Cardiovasc. Res. 18: 604–612, 1984.
Yazaki, Y., Ueda, S., Nagai, R. and Shimada, K. Circ. Res. 45: 522–527, 1979.
Buckingham, M.E. Essays in Biochemistry 20: 77–109, 1985.
Mayer, Y., Czosnek, H., Zeelon, P.E., Yaffe, D. and Nudel, U. Nucleic Acids Res. 12: 1087–2000, 1984.
Minty, A.J., Alonso, S., Caravatti, M. and Buckingham, M.E. Cell 30: 185–192, 182.
Lompre, A.M., Schwartz, K., d’Albis, A., Lacombe, G., Van Thiem, N.G. and Swynghedauw, B. Nature 282: 105–107, 1979.
Litten, R.Z., Martin, B.J., Low, R.B. and Alpert, N.R. Circ Res. 50: 856–864, 1982.
Mercadier, J.J., Bouveret, P., Gorza, L., Schiaffino, S., Clark, W.A., Zak, R., Swynghedauw, B. and Schwartz, K. Circ. Res. 53: 52–62, 1983.
Gorza, L., Mercadier, J.J., Schwartz, K., Thornell, L.E. Sartore, S. and Schiaffino, S. Circ. Res. 54: 694–702, 1984.
Tsuchimochi, H., Sugi, M., Kuro-o, M., Ueda, S., Takaku, F., Furuta, S.I., Shirai, T. and Yazaki, Y. J. Clin. Invest. 74: 662–665, 1984.
Bouvagnet, P., Léger, J., Dechesne, C.A., Dureau, G., Anoal, M. and Legér, J.J. Circulation 72: 272–279, 1985.
Schwartz, K. and Mercadier, J.J. In: Methods of Enzymatic Analysis (Ed. U.V. Bergmeyers), VHC, Weinheim, vol.IV, 1986, pp. 225–238.
Izumo, S., Nadal-Ginard, B. and Mahdavi, V. Science 231: 597–600, 1986.
Chizzonite, R.A., Everett, A.W., Prior, G. and Zak, R. J. Biol. Chem. 259: 15564–15571, 1984.
Banerjee, S.K. Circ. Res. 52: 131–136, 1983.
Samuel, J.L., Rappaport, L., Syrovy, I., Wisnewsky, C, Marotte, F., Whalen, R.G. and Schwartz, K. Am. J. Physiol. 250: 331–341, 1986.
Vandekerckhove, J., Bugaisky, G. and Buckingham, M. J. Biol. Chem. 241: 1836–1843, 1986.
Gunning, P., Ponte, P., Blau, H. and Kedes, L. Molec. Cell. Biol. 3: 1985–1995, 1983.
Schwartz, K., de la Bastie, D., Bouveret, P., Oliviero, P., Alonso, S. and Buckingham, M. Circ. Res. in press.
Alonso, S., Minty, A., Bourlet, Y. and Buckingham, M.E. J. Mol. Evol. 23 in press, 1986.
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© 1987 Martinus Nijhoff Publishing, Boston
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Mercadier, J.J. et al. (1987). Isomyosins and Isoactins in Mammalian Myocardium. In: Dhalla, N.S., Pierce, G.N., Beamish, R.E. (eds) Heart Function and Metabolism. Developments in Cardiovascular Medicine, vol 66. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2053-1_21
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DOI: https://doi.org/10.1007/978-1-4613-2053-1_21
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