Abstract
The calcium concept of excitation-contraction coupling evolved from four basic findings:
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1)
The contractile machinery of all kinds of muscles contains calcium sensitive target proteins with similar calcium affinity (1–3).
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2)
During muscle contraction, the sarcoplasmic calcium level rises transiently from 0.1 µM to 10 µM (4–6).
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3)
Active calcium pumps guarantee a low resting calcium level, and a fast removal of calcium from the contractile proteins for relaxation (7–9), and
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4)
specific calcium storing and releasing structures supply the contractile machinery with calcium (10–12).
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© 1987 Martinus Nijhoff Publishing, Boston
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Hasselbach, W. (1987). Mechanisms of Sarcoplasmic Reticulum Functions and Consequences for Muscle Activity. In: Dhalla, N.S., Pierce, G.N., Beamish, R.E. (eds) Heart Function and Metabolism. Developments in Cardiovascular Medicine, vol 66. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2053-1_15
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DOI: https://doi.org/10.1007/978-1-4613-2053-1_15
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